颈内动脉狭窄影响颈总动脉血流电导率与电阻抗的数值仿真  

Numerical Simulation of Blood Flow Conductivity and Electrical Impedance in Common Carotid Artery Affected by Internal Carotid Artery Stenosis

作　　者：占琛林 李泳江[2] 陈东[3] 覃开蓉[2] Zhan Chenlin;Li Yongjiang;Chen Dong;Qin Kairong(School of Optoelectronic Engineering and Instrumentation Science,Dalian University of Technology,Dalian 116024,China;School of Biomedical Engineering,Faculty of Medicine,Dalian University of Technology,Dalian 116024,China;Affiliated Central Hospital,Dalian University of Technology,Dalian 116033,China)

机构地区：[1]大连理工大学光电工程与仪器科学学院,大连116024 [2]大连理工大学医学部生物医学工程学院,大连116024 [3]大连理工大学附属中心医院,大连116033

出　　处：《水动力学研究与进展（A辑）》2023年第4期637-645,共9页Chinese Journal of Hydrodynamics

基　　金：科技部国家重点研发计划项目(2020YFC2004400);辽宁省自然科学基金项目(2021-YGJC-09);中央高校基本科研业务项目(DUT22YG226,DUT22LAB106)。

摘　　要：颈总动脉汇集了来自上游心脏与下游脑血管床的血流动力学信息,是心脑血管疾病早期诊断的“窗口”,而融合生物电阻抗技术的动脉血流动力学参数检测分析具有无创、经济、便携及可穿戴实时监测等优势。然而,不同程度的颈内动脉狭窄影响颈动脉分叉的血流动力学参数,进而影响颈总动脉血流电导率与电阻抗的规律尚不明确,限制了电阻抗技术在颈内动脉狭窄程度检测与评估中的应用。该文首先基于颈动脉分叉部位的影像学数据建立三维血管模型及理想化的颈内动脉狭窄模型,进一步利用超声血流检测数据通过计算流体力学分析,研究了不同狭窄程度颈内动脉对颈动脉分叉部位血流速度、血压、壁面剪应力分布以及颈总动脉血流电导率和电阻抗的影响。结果显示,在保持颈总动脉入口流量波形不变的情况下,随着颈内动脉狭窄程度的增加,颈动脉电导率受到狭窄区域和回流区域中流速和轴心距离的影响,颈总动脉电阻抗检测信号呈现先减小后增大的趋势,提示颈总动脉血流电导率和电阻抗与颈内动脉狭窄程度密切相关。该文结果为拓展生物电阻抗检测技术在颈内动脉狭窄程度评估的应用提供了一定的理论依据。The common carotid artery collects the hemodynamic information from the upstream heart and the downstream cerebrovascular bed,which is the"window"for the early diagnosis of cardiovascular and cerebrovascular diseases.The detection and analysis of arterial hemodynamic parameters with bioelectrical impedance technology have the advantages of non-invasive,economical,portable and wearable real-time monitoring.However,it is not clear how different degrees of internal carotid artery stenosis affect the hemodynamic parameters in the carotid bifurcation,and further influence the blood flow conductivity and electrical impedance of the common carotid artery,which limits the application of electrical impedance technology in the detection and evaluation of the stenosis degree of internal carotid artery.In this study,a three-dimensional vascular model and an idealized internal carotid artery stenosis model are established based on the imaging data of the carotid artery bifurcation.Further,the effects of different stenosis degrees of internal carotid artery on the blood flow velocity,blood pressure,wall shear stress distribution,the electrical conductivity and impedance of the common carotid artery are studied using the ultrasonic blood flow detection data and computational fluid dynamics analysis.The results show that,under the condition of the consistent flow rate waveform at the common carotid artery inlet,with the increase in stenosis degree of internal carotid artery,the carotid artery conductivity is affected by the flow velocity and axial distance in the stenosis and reflux regions,while the electrical impedance of the common carotid artery decreases first and then increases.It is suggested that the electrical conductivity and impedance of the common carotid artery are closely related to the stenosis degree of internal carotid artery.The results of this study provide a theoretical basis for expanding the application of bioelectrical impedance detection technology in the evaluation of internal carotid artery stenosis deg

关 键 词：颈总动脉 血管狭窄 血流动力学 电导率 电阻抗 

分 类 号：R318.01[医药卫生—生物医学工程]