甲型流感病毒感染动物模型的研究进展  

Advances in animal models of influenza A virus infection

作　　者：王忆菲 黄维金[1] 耿彦生 赵晨燕[1] Wang Yifei;Huang Weijin;Geng Yansheng;Zhao Chenyan(Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,Key Laboratory of Biological Product Quality Research and Evaluation of National Medical Products Administration,Division of HIV/AIDS and Sex-transmitted Virus Vaccines,National Institutes for Food and Drug Control,Beijing 102629,China;Department of Preventive Medicine,School of Public Health,Hebei University,Baoding 071000,China)

机构地区：[1]中国食品药品检定研究院艾滋病性病病毒疫苗室,国家卫生健康委员会生物技术产品检定方法与标准化重点实验室,国家药品监督管理局生物制品质量研究与评价重点实验室,北京102629 [2]河北大学公共卫生学院预防医学系,保定071000

出　　处：《中华微生物学和免疫学杂志》2023年第9期727-732,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家重点研发计划(2021YFC2301700)。

摘　　要：流行性感冒(简称流感)在全球范围内引发了较高的发病率和死亡率,严重危害人类健康和生命,流感病毒的不断变异为流感的预防和治疗带来新的挑战。动物模型为全面认知流感病毒发病机制、传播机制、疫苗开发及治疗效果评估提供便利,不同研究中流感病毒动物感染模型的构建与使用存在差异,不同动物模型的应用也各具特点。本文综述了多种动物模型的构建及使用现状,总结了其在抗体、药物和疫苗效力评估方面的优势和局限性,为将来选择及优化动物模型提供参考。Influenza has caused high morbidity and mortality worldwide,seriously endangering human health and life.The continuous mutation of influenza virus has brought new challenges to the prevention and treatment of influenza.Animal models provide convenience for a comprehensive understanding of influenza virus pathogenesis,transmission mechanism,vaccine development,and evaluation of therapeutic effects.The construction and use of animal models of influenza virus infection vary in different studies,and the application of different animal models also has its own characteristics.This article reviewed the current status of the construction and use of various animal models,and summarized the advantages and limitations of animal models in evaluating the efficacy of antibodies,drugs and vaccines,with the aim of providing reference for the selection and optimization of animal models in the future.

关 键 词：甲型流感病毒 动物模型 优点和局限性 感染 疫苗 

分 类 号：R511.7[医药卫生—内科学] R-332[医药卫生—临床医学]