SARS-CoV-2疫苗不同动物模型攻毒试验常见问题及考虑  

Common problems and considerations in challenge tests of different animal models of SARS-CoV-2 vaccine

作　　者：吴爽 王寅(综述) 孙涛(审校) WU Shuang;WANG Yin;SUN Tao(Center for Drug Evaluation,National Medical Products Administration,Beijing 100022,China)

机构地区：[1]国家药品监督管理局药品审评中心,北京100022

出　　处：《中国生物制品学杂志》2023年第9期1149-1152,共4页Chinese Journal of Biologicals

摘　　要：动物攻毒试验作为严重急性呼吸综合征冠状病毒2(severe acute respiratory symptom coronavirus 2,SARS-CoV-2)疫苗有效性评价的有效手段,选择合适的动物模型及合理试验设计对获取有效性、安全性信息及支持临床试验十分重要。目前,非临床常用动物模型包括转基因小鼠、非人灵长类动物、仓鼠、雪貂等。本文就非临床试验中常用动物模型及其在应用中遇到的问题作一综述。Animal challenge test is an effective means to study the efficacy of severe acute respiratory symptom coronavirus 2(SARS-CoV-2)vaccine.The appropriate animal models and reasonable experimental design play an important role in obtaining efficacy and safety information,as well as supporting clinical trials.At present,common non-clinical animal models include transgenic mice,non-human primates,hamsters,ferrets and so on.This paper reviews the common animal models used in non-clinical trials and the problems encountered in their application.

关 键 词：SARS-CoV-2疫苗 攻毒试验 动物模型 

分 类 号：R392-33[医药卫生—免疫学]