甲磺酸萘莫司他的临床应用及研究进展  

The clinical application and reseach progress of nafamostat mesilate

作　　者：许威 冷菊 Xu Wei;Leng Ju(Department of pancreatic surgery,Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《首都食品与医药》2023年第19期16-18,共3页Capital Food Medicine

摘　　要：甲磺酸茶莫司他(nafamostat mesilate,NM)是一种广谱强效的丝氨酸蛋白酶抑制剂,临床主要用于治疗急性胰腺炎(acute pancreatitis,AP)、弥散性血管内凝血症(disseminated intravascular coagulation,DiC),同时也可作为体外抗凝的抗凝剂。因其快速的代谢速度及透析性,所以具有局部抗凝作用。针对围手术期及有出血倾向的患者,NM的这种局部抗凝作用可能使其成为潜在的优势抗凝剂。笔者就NM的作用及在临床中的应用现状,特别是在体外抗凝中的应用及其潜在价值进行综述。As a broad spectrum and strong serine protease inhibitor,nafamostat mesilate(NM)has strong inhibitory effect on multiple serine proteases,such as trypsin,thrombin,plasminase and complement components,and is mainly used for the treatment of acute pancreatitis(AP),dsseminated intravascular coagulation(DIC),and can be used as an anticoagulant in extracorporeal circulation.Because of its rapid metabolic rate and dialysate,it has the characteristics of local anticoagulation,that is,it only plays an anticoagulation role in the extracorporeal circulation loop and does not have an anticoagulation effect on the internal circulation.Because of this local anticoagulant effect,NM may be a potentially advantageous anticoagulant for perioperative and bleeding situations.Here,we reviewed the application of NM in clinical application,especially in extracorporeal circulation and its potential value.

关 键 词：甲磺酸萘莫司他 急性胰腺炎 持续性肾脏替代治疗 体外膜氧合 弥散性血管内凝血症 

分 类 号：R973.2[医药卫生—药品]