益气维血胶囊联合复方硫酸亚铁治疗妊娠期缺铁性贫血的临床研究  

Clinical study on Yiqi Weixue Capsules combined with compound ferrous sulfate in treatment of iron-deficiency anemia during pregnancy

作　　者：王俊茹 刘慧丽 郝俊兰 韩兴思 王晶 WANG Jun-ru;LIU Hui-li;HAO Jun-lan;HAN Xing-si;WANG Jing(Department of Pregnancy and Perinatal Care,Xingtai Third Hospital,Xingtai 054000,China;Department of obstetrics,Xingtai Third Hospital,Xingtai 054000,China)

机构地区：[1]邢台市第三医院孕产期保健科,河北邢台054000 [2]邢台市第三医院产一科,河北邢台054000

出　　处：《现代药物与临床》2023年第9期2314-2317,共4页Drugs & Clinic

基　　金：邢台市科技支撑计划项目(2019ZC264)。

摘　　要：目的探讨益气维血胶囊联合复方硫酸亚铁颗粒治疗妊娠期缺铁性贫血的临床疗效。方法选取2020年4月—2022年12月邢台市第三医院收治的82例妊娠期缺铁性贫血患者,根据随机数字表法将所有患者分为对照组和治疗组,每组各41例。对照组患者温水冲服复方硫酸亚铁颗粒,1袋/次,1次/d。治疗组在对照组基础上口服益气维血胶囊,4粒/次,3次/d。两组连续治疗2个月。观察两组的临床疗效,比较两组治疗前后红细胞计数(RBC)、血红蛋白(Hb)、平均红细胞血红蛋白浓度(MCHC)、红细胞比容(HCT)、铁调素、可溶性转铁蛋白受体(sTfR)、铁蛋白(SF)水平。结果治疗后,治疗组患者的总有效率为95.12%,对照组的总有效率为80.49%,组间比较差异显著(P<0.05)。治疗后,两组的RBC、Hb、MCHC、HCT高于治疗前(P<0.05);治疗后,治疗组的RBC、Hb、MCHC、HCT高于对照组,差异有统计学意义(P<0.05)。治疗后,两组铁调素、SF高于治疗前,sTfR低于治疗前(P<0.05);治疗组的铁调素、SF高于对照组,sTfR低于对照组,差异有统计学意义(P<0.05)。结论益气维血胶囊联合复方硫酸亚铁颗粒治疗妊娠期缺铁性贫血的疗效确切,能提高RBC、Hb水平,改善铁代谢水平。Objective To investigate the clinical effect of Yiqi Weixue Capsules combined with Compound Ferrous Sulfate Granules on iron-deficiency anemia during pregnancy.Methods Patients(82 cases)with iron-deficiency anemia during pregnancy in Xingtai Third Hospital from April 2020 to December 2022 were divided into control and treatment groups according to the random number table method,and each group had 41 cases.Patients in the control group were po administered with Compound Ferrous Sulfate Granules,1 bag/time,once daily.Patients in the treatment group were po administered with Yiqi Weixue Capsules on the basis of the control group,4 grains/time,three times daily.Patients in two groups were treated for 2 months.After treatment,the clinical efficacies were evaluated,and the RBC,Hb,MCHC,HCT,ferromodulin,sTfR,and SF in two groups were compared.Results After treatment,the total effective rate of patients in the treatment group was 95.12%,while that of the control group was 80.49%,with significant differences between the groups(P<0.05).Afer treatment,RBC,Hb,MCHC,and HCT of two groups were higher than those before treatment(P<0.05).After treatment,RBC,Hb,MCHC,and HCT of the treatment group were significantly higher than those of the control group(P<0.05).Affer treatment,HAMP and SF in two groups were higher than those before treatment,but sTfR in two groups was lower than those before treatment(P<0.05).HAMP and SF in the treatment group were higher than those of the control group,but sTfR in the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Yiqi Weixue Capsules combined with Compound Ferrous Sulfate Granules is effective in treatment of iron-deficiency anemia during pregnancy,can increase RBC and Hb levels,improve iron metabolism levels.

关 键 词：益气维血胶囊 复方硫酸亚铁颗粒 妊娠期缺铁性贫血 红细胞计数 血红蛋白 平均红细胞血红蛋白浓度 红细胞比容 铁调素 可溶性转铁蛋白受体 铁蛋白 

分 类 号：R984[医药卫生—药品]