2型糖尿病治疗药物对饥饿素影响的研究进展  

Research progress on effect of therapeutic drugs for type 2 diabetes on ghrelin

作　　者：刘柔 冷玉琳 贾华楠[1] 刘雪辉[1] LIU Rou;LENG Yu-lin;JIA Hua-nan;LIU Xue-hui(Hospital of Chengdu University of TCM,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院,四川成都610075

出　　处：《现代药物与临床》2023年第9期2357-2361,共5页Drugs & Clinic

基　　金：国家自然科学基金资助项目(81904082)。

摘　　要：2型糖尿病“多食易饥”现象控制难度大,大量进食进一步促进病情进展。饥饿素是空腹时由胃底细胞分泌的一种食欲调节激素,是目前已知的唯一与食欲直接相关的激素。饥饿素作为与食欲密切相关的激素,二甲双胍、噻唑烷二酮类药物、α-葡萄糖苷酶抑制剂、二肽基肽酶-4(DPP-4)抑制剂、胰高血糖素样肽-1(GLP-1)类似物、钠–葡萄糖共转运蛋白2(SGLT-2)抑制剂等2型糖尿病治疗药物均对其水平产生一定的影响。综述了各类常见2型糖尿病治疗药物对血浆饥饿素水平的影响,为以饥饿素作为靶点的2型糖尿病的防治研究提供新思路。It is difficult to control the phenomenon of"overeating and easy hunger"in type 2 diabetes.Eating in large quantities further promotes the progress of the disease.Ghrelin is an appetite-related hormone secreted by gastric fundus cells under fasting state,and it is the only known hormone directly related to appetite.As a hormone closely related to appetite,the level of ghrelin could be affected by type 2 diabetes drugs,such as metformin,thiazolidinediones,α-glycosidase inhibitors,dipeptidyl peptidase-4(DPP-4)inhibitors,glucagon-like petide-1(GLP-1)analogues,and sodium-glucose cotransporter-2(SGLT-2)inhibitors.This article reviews the effects of various common therapeutic drugs for type 2 diabetes on plasma ghrelin levels,so as to provide new ideas for the prevention and treatment of type 2 diabetes with ghrelin as a target.

关 键 词：二甲双胍 噻唑烷二酮类药物 Α-葡萄糖苷酶抑制剂 二肽基肽酶-4抑制剂 胰高血糖素样肽-1类似物 钠–葡萄糖共转运蛋白2抑制剂 2型糖尿病 饥饿素 

分 类 号：R965[医药卫生—药理学]