双胎妊娠并发子痫前期妊娠结局及危险因素分析  

Pregnancy outcomes of twin pregnant women with preeclampsia and its risk factors analysis

作　　者：孙璐[1,2] 周洁 戚婷婷 孙丽洲[1] SUN Lu;ZHOU Jie;QI Tingting;SUN Lizhou(The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu Province,210029;Huai'an Maternal and Child Health Care Hospital,Huai'an,Jiangsu Province)

机构地区：[1]南京医科大学第一附属医院,210029 [2]江苏省淮安市妇幼保健院

出　　处：《中国计划生育学杂志》2023年第10期2462-2466,共5页Chinese Journal of Family Planning

摘　　要：目的:探究双胎妊娠并发子痫前期(PE)妊娠结局及其相关危险因素。方法:回顾性选取本院2021年5月-2022年9月收治的55例双胎妊娠并发PE孕妇(110例新生儿)纳入PE组,双胎妊娠正常孕妇55例(110例新生儿)纳入非PE组。比较两组一般资料、妊娠结局,分析双胎妊娠孕妇并发PE的危险因素。结果:PE组孕前体质指数(BMI)(30.7±3.5 kg/m^(2))大于正常组(28.5±2.9 kg/m^(2)),辅助生殖技术(ART)受孕、单绒毛膜性双胎及贫血占比均高于正常组,血红蛋白、血清白蛋白、血小板水平均低于正常组;PE组早产(65.5%)、产后出血(12.7%)发生率均高于正常组(45.5%、1.8%);新生儿平均体重(2.4±0.4 kg)低于正常组(2.6±0.5 kg),低体重儿占比(58.2%)高于正常组(44.6%)(均P<0.05)。BMI≥24 kg/m^(2)、ART受孕及单绒毛膜性均是导致双胎妊娠孕妇并发PE的危险因素(P<0.05)。结论:并发PE孕妇贫血及早产、产后出血、低体重儿等不良结局发生率升高,BMI≥24 kg/m^(2)、ART受孕及单绒毛膜性均是导致双胎妊娠并发PE的危险因素,临床应加强双胎妊娠规范化管理,预防PE发生。Objective:To explore the pregnancy outcomes of twin pregnant women with preeclampsia(PE),and to analyze the related risk factors of PE.Methods:55 women(110 fetuses) with twin pregnancy and PE who were treated in hospital from May 2021 to September 2022 were selected in study group retrospectively,and another 55 women(110 fetuses) with twin pregnancy but without PE were included in control group during the same period.The general data and the pregnancy outcomes of the women were compared between the two groups.The risk factors of PE of the women with twin pregnancy were analyzed.Results:The pre-pregnancy body mass index(BMI) of the women(30.7±3.5kg/m^(2)) in the study group was significantly higher than that(28.5±2.9kg/m^(2)) of the women in the control group.The proportions of the pregnancy after assisted reproductive technology(ART),the monochorional twins,and the anemia of the women in the study group were significantly higher than those of the women in the control group.The levels of hemoglobin,serum albumin,and platelet of the women in the study group were significantly lower than those of the women in the control group.The incidences of preterm birth(65.5%) and postpartum hemorrhage(12.7%) of the women in the study group were significantly higher than those(45.5% and 1.8%) of the women in the control group.The mean body weight(2.4±0.4 kg) of the neonates in the study group was significantly lower than that(2.6±0.5 kg) of the neonates in the control group,and the proportion of the infant of low-birth weight(58.2%) in the study group was significantly higher than that(44.6%) in the control group(all P<0.05).The BMI≥24kg/m^(2),pregnancy after ART,and the monochorionic status of the twins of the women were the risk factors of their PE occurrence(P<0.05).Conclusion:The rates of the adverse pregnancy outcomes,such as anemia complication,premature delivery,postpartum hemorrhage,and the infant of low-birth weight,of the pregnant women with PE increase.The BMI≥24kg/m^(2),the pregnancy after ART,and the monoch

关 键 词：双胎妊娠 子痫前期 不良妊娠结局 危险因素 

分 类 号：R714.244[医药卫生—妇产科学]