低分子肝素联合复方氨基酸、硫酸镁治疗宫内胎儿生长受限的效果及对IGF-2、IGFBP-3的影响  

Effect of low molecular weight heparin combined with compound amino acid and magnesium sulfate in the treatment of intrauterine fetal growth restriction and its influences on IGF-2 and IGFBP-3

作　　者：雷艳芳 肖玲 LEI Yanfang;XIAO Ling(Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院,陕西汉中723000

出　　处：《临床医学研究与实践》2023年第30期105-108,113,共5页Clinical Research and Practice

摘　　要：目的分析低分子肝素联合复方氨基酸、硫酸镁治疗宫内胎儿生长受限的效果。方法选择2019年1月至2022年2月我院的80例宫内胎儿生长受限孕产妇为研究对象,根据入院时间不同将其分为对照组(2019年1月至2021年1月)和观察组(2021年2月至2022年2月),各40例。对照组接受复方氨基酸+硫酸镁治疗,观察组在对照组基础上加用低分子肝素治疗。比较两组的治疗效果。结果治疗后,观察组的胎儿股骨长(FL)、双顶径(BPD)、腹围(AC)、头围(HC)大于对照组,差异具有统计学意义(P<0.05)。分娩后,观察组的脐血清胰岛素样生长因子-2(IGF-2)水平高于对照组,胰岛素样生长因子结合蛋白-3(IGFBP-3)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的脐动脉阻力指数(RI)、收缩期与舒张期流速比(S/D)、搏动指数(PI)低于对照组,舒张末期血流速度(EDV)高于对照组,差异具有统计学意义(P<0.05)。观察组的不良妊娠结局总发生率低于对照组,差异具有统计学意义(P<0.05)。结论低分子肝素联合复方氨基酸、硫酸镁治疗宫内胎儿生长受限效果显著,可改善胎儿脐动脉血流,调节IGF-2、IGFBP-3表达,改善胎儿生长发育情况,降低不良妊娠结局发生情况。Objective To analyze the effect of low molecular weight heparin combined with compound amino acid and magnesium sulfate in the treatment of intrauterine fetal growth restriction.Methods A total of 80 pregnant women with intrauterine fetal growth restriction in our hospital from January 2019 to February 2022 were selected as the research objects.According to the different admission time,the pregnant women were divided into control group(from January 2019 to January 2021)and observation group(from February 2021 to February 2022),with 40 cases in each group.The control group was treated with compound amino acid+magnesium sulfate,and the observation group was treated with low molecular weight heparin on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the fetal femur length(FL),biparietal diameter(BPD),abdomina circumference(AC)and head circumference(HC)in the observation group were greater than those in the control group,and the differences were statistically significant(P<0.05).After delivery,the level of umbilical serum insulin-like growth factor-2(IGF-2)in the observation group was higher than that in the control group,and the level of insulin-like growth factor-binding protein-3(IGFBP-3)was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the umbilical artery resistance index(RI),systolic to diastolic velocity ratio(S/D)and pulsatility index(PI)in the observation group were lower than those in the control group,and the end diastolic velocity(EDV)was higher than that in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Low molecular weight heparin combined with compound amino acid and magnesium sulfate is effective in the treatment of intrauterine fetal growth restriction,it can impr

关 键 词：低分子肝素 复方氨基酸 硫酸镁 宫内胎儿生长受限 生长发育 

分 类 号：R714.5[医药卫生—妇产科学]