基于数据挖掘的化疗后骨髓抑制防治中药用药规律探讨  

Medication Rules of Traditional Chinese Medicine for Preventing and Treating Bone Marrow Suppression After Chemotherapy Based on Data Mining

作　　者：赵薇[1] 顾媛媛[1] 柳芳[2] 刘洁 马丽娜 郭媛媛 曹俊岭 贾立群[2] 何婷[1] ZHAO Wei;GU Yuanyuan;LIU Fang;LIU Jie;MA Lina;GUO Yuanyuan;CAO Junling;JIA Liqun;HE Ting(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing,China 100078;China-Japan Friendship Hospital,Beijing,China 100078;Children′s Hospital Affiliated to the Capital Institute of Pediatrics,Beijing,China 100020)

机构地区：[1]北京中医药大学东方医院,北京100078 [2]中日友好医院,北京100078 [3]首都儿科研究所附属儿童医院,北京100020

出　　处：《中国药业》2023年第20期69-72,共4页China Pharmaceuticals

基　　金：北京市中医管理局项目[2100601-中医(民族医)药专题]。

摘　　要：目的探讨防治化学药物治疗(简称化疗)后骨髓抑制的中药的使用规律。方法通过中国知网(CNKI)及万方数据库检索相应中药用药规律的文献,检索时限为1999年1月至2020年10月。统计相关中药特性及使用频次,并进行聚类分析和关联分析。结果治疗化疗后骨髓抑制的中药,功效以补虚为主,性味归经以温(含微温)性,甘味,脾、肝、肾、肺经为主;高频中药形成4个聚类方;强关联规则的药对为黄芪-白术、黄芪-当归、白术-茯苓等。结论化疗后骨髓抑制的治疗方药具有气血双补、脾肾同治的特点,组方中药以补虚药为主,药对以补气健脾、益气养血药相互配伍为主。该研究可为临床治疗化疗后骨髓抑制用药提供参考。Objective To investigate the medication rules of traditional Chinese medicine(TCM)for preventing and treating bone marrow suppression after chemotherapy.Methods Relevant studies on the medication rules of TCM in the CNKI and WanFang databases from January 1999 to October 2020 were searched,the characteristics and usage frequency of relevant TCM were collected,the cluster analysis and correlation analysis were performed.Results The efficacy of TCM in the treatment of bone marrow suppression after chemotherapy focused on tonifying deficiency,the nature was mainly warm(including slightly warm),the flavor was mainly sweet,the TCM mainly returned to spleen,liver,kidney and lung meridians.Four clustering formulas were formed in the high-frequency TCM.The drug pairs with strong association rules were Astragali Radix-Atractylodis Macrocephalae Rhizoma,Astragali Radix-Angelicae Sinensis Radix and Atractylodis Macrocephalae Rhizoma-Poria.Conclusion The formulas in the treatment of bone marrow suppression after chemotherapy has the characteristics of tonifying Qi and blood,treating disease from spleen and kidney.The TCM in the formulas focus on tonifying deficiency,and the drug pairs focus on the compatibility of tonifying-Qi and strengthening-spleen drugs,invigorating-Qi and enriching-blood drugs.This study can provide a reference for clinical use of drugs in the treatment of bone marrow suppression after chemotherapy.

关 键 词：中药 化疗 骨髓抑制 数据挖掘 用药监护 

分 类 号：R932[医药卫生—生药学] R255.7[医药卫生—药学]