观察富马酸亚铁多库酯钠胶囊在妊娠期缺铁性贫血中的应用效果及不良反应发生情况  

Observation on the effect and adverse reactions of ferrous eumanate and docusate sodium capsules in iron-deficiency anemia during pregnancy

作　　者：初振豪[1] CHU Zhen-hao(Department of Obstetrics,Shengjing Hospital Affiliated to China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属盛京医院产科,110001

出　　处：《中国实用医药》2023年第19期92-94,共3页China Practical Medicine

摘　　要：目的观察富马酸亚铁多库酯钠胶囊在妊娠期缺铁性贫血中的应用效果及不良反应发生率。方法106例妊娠期缺铁性贫血患者,按照随机数字表法分为对照组和观察组,各53例。对照组采用多糖铁复合物治疗,观察组采用富马酸亚铁多库酯钠胶囊治疗。对比两组血象[红细胞计数(RBC)、血红蛋白(Hb)]和铁代谢[血清铁(SI)、血清铁蛋白(SF)]水平,不良反应发生率。结果治疗前,两组患者的RBC、Hb、SI、SF水平对比,差异无统计学意义(P>0.05);治疗后,两组患者的RBC、Hb、SI、SF水平均高于本组治疗前,且观察组患者的RBC(4.15±0.35)×10^(12)/L、Hb(115.34±5.26)g/L、SI(15.47±4.15)μmol/L、SF(70.25±6.67)μg/L均高于对照组的(3.91±0.41)×10^(12)/L、(112.31±5.25)g/L、(13.24±3.23)μmol/L、(65.74±6.56)μg/L,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为5.66%,低于对照组的18.87%,差异具有统计学意义(P<0.05)。结论妊娠期缺铁性贫血患者采用富马酸亚铁多库酯钠胶囊可有效提高血象和铁代谢水平,效果显著,且不良反应少,安全性可。Objective To observe the effect and adverse reactions of ferrous eumanate and docusate sodium capsules in iron-deficiency anemia during pregnancy.Methods A total of 106 patients with irondeficiency anemia during pregnancy were divided into control group and observation group according to the random numerical table,with 53 cases in each group.The control group was treated with polysaccharide iron complex,and the observation group was treated with ferrous eumanate and docusate sodium capsules.The hemogram[red blood cell count(RBC),hemoglobin(Hb)],iron metabolism[serum iron(SI),serum ferritin(SF)],and the incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in RBC,Hb,SI and SF levels between the two groups(P>0.05).After treatment,the levels of RBC,Hb,SI and SF in both groups were higher than those before treatment in this group;the observation group had RBC of(4.15±0.35)×10^(12)/L,Hb of(115.34±5.26)g/L,SI of(15.47±4.15)μmol/L,and SF of(70.25±6.67)μg/L,which were higher than those of(3.91±0.41)×10^(12)/L,(112.31±5.25)g/L,(13.24±3.23)μmol/L,and(65.74±6.56)μg/L in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.66%,which was lower than that of 18.87%in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of ferrous eumanate and docusate sodium capsules on patients with iron-deficiency anemia during pregnancy is remarkable,which can effectively improve hemogram and iron metabolism level,and has fewer adverse reactions and high safety.

关 键 词：妊娠期 缺铁性贫血 富马酸亚铁多库酯钠 效果 不良反应 

分 类 号：R714.254[医药卫生—妇产科学]