Stereoselective construction of atropisomers featuring a C-N chiral axis  

作　　者：Yong-Jie Wu Gang Liao Bing-Feng Shi 

机构地区：[1]Center of Chemistry for Frontier Technologies,Department of Chemistry,Zhejiang University,Hangzhou 310027,China [2]Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001,China [3]Department of Chemistry,National University of Singapore,Singapore 117543,Singapore [4]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China

出　　处：《Green Synthesis and Catalysis》2022年第2期117-136,共20页绿色合成与催化（英文）

基　　金：Financial support from the National Natural Science Foundation of China(Nos.21925109 and 21772170);the Open Research Fund of School Chemistry and Chemical Engineering,Henan Normal University and the Center of Chemistry for Frontier Technologies of Zhejiang University is gratefully acknowledged.

摘　　要：Atropisomeric C-N compounds belong to an important class of axially chiral compounds.However,whereas the asymmetric synthesis of biaryl atropisomers have been well established,general and efficient strategies to access single enantiomers of C-N atropisomers are still rare.Until recently,innovative methods have been developed,providing new opportunities for the highly stereoselective synthesis of this vital class of atropisomers.Herein,we comprehensively summarize the development in this emerging field and give some insights into future advance.Emphasis is placed on the synthetic strategies.

关 键 词：ATROPISOMERS C-N Chiral axis Asymmetric synthesis STEREOSELECTIVITY 

分 类 号：O62[理学—有机化学]