Synthesis of 3-thiocyanated chromones via TCCA/NH_(4)SCN-mediated cyclization/thiocyanation of alkynyl aryl ketones  

作　　者：Jiaxi Xiao Zhenkang Ai Xuemin Li Sanqing Tao Bingyue Zhao Xiaofan Wang Xinbo Wang Yunfei Du 

机构地区：[1]Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China [2]School of Environmental Science and Engineering,Shandong University,Qingdao 266237,China

出　　处：《Green Synthesis and Catalysis》2022年第2期198-201,共4页绿色合成与催化（英文）

基　　金：We acknowledge the National Natural Science Foundation of China(No.22071175)for financial support;X.B.Wang thanks the financial support from the National Natural Science Foundation of China(Nos.21908018,22078174),and Qi Lu Young Scholar Start-up Foundation of Shandong University.

摘　　要：3-Thiocyanated chromones was conveniently synthesized from alkynyl aryl ketones using commercially available,inexpensive trichloroisocyanuric acid(TCCA)as oxidant and NH_(4)SCN as thiocyanato(SCN)source.This metalfree approach is postulated to first in situ generate thiocyanogen chloride(Cl-SCN)from the reaction of TCCA and NH_(4)SCN,followed by a rare efficient electrophilic thiocyano oxyfunctionalization of alkynes enabled by the reactive electrophilic species generated thereof.

关 键 词：THIOCYANATION CYCLIZATION TCCA NH_(4)SCN CHROMONES 

分 类 号：O62[理学—有机化学]