TMSCF_(2)Br as both a C1 synthon and a F1 reagent  

作　　者：Danhua Ge Zhenhua Jia Xuegiang Chu 

机构地区：[1]Institute of Advanced Synthesis,School of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 211816,China

出　　处：《Green Synthesis and Catalysis》2022年第4期303-305,共3页绿色合成与催化（英文）

基　　金：We gratefully acknowledge the financial support from the Start-up Grant in Nanjing Tech University(Nos.39837118,39837146);the National Natural Science Foundation of China(No.22001121).

摘　　要：This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.

关 键 词：TMSCF_(2)Br C1 synthon F1 reagent C-F functionalization Organofluoride 

分 类 号：O62[理学—有机化学]