Benzaldehyde lyase-catalyzed enantioselective C-C bond formation and cleavage:A review  

作　　者：Zhiran Ju Junde Xu Zhiyun Li Jingjie Fang Menglan Li Daniel C.Howell FenEr Chen 

机构地区：[1]Institute of Pharmaceutical Science and Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Shanghai 200433,China [4]Department of Pharmaceutical Sciences,Oregon State University,Corvallis 97331,United States

出　　处：《Green Synthesis and Catalysis》2022年第4期317-326,共10页绿色合成与催化（英文）

基　　金：The author would like to thank Dr.K.Kaliyaperumal,Dr.M.Fredimoses and Dr.B.Sachin for their careful revisions of this work.

摘　　要：Benzaldehyde lyase(BAL)is an enzyme which was originally found from Pseudomonas fluorescens biovar I.It has long been used in the formation of a C-C bond.BAL can exclusively yield(R)-enantioselective products from the synthesis ofα-hydroxy ketones and has so far been explored as an important enzyme to prepare the corresponding intermediate of pharmaceuticals.Due to its substrate spectrum and stereospecificity,this enzyme extends the synthetic potential for carboligations appreciably.In this review,we highlight the biotransformation applications of BAL in recent years,some of which have achieved intriguing results and provided the theoretical basis for drug development and industrial purpose in the future.

关 键 词：Benzaldehyde lyase Pseudomonas fluorescens biovar I C-C bond (R)-Enantioselective 

分 类 号：O62[理学—有机化学]