NiH-catalyzed asymmetric hydroalkynylation of α,β-unsaturated amides  

作　　者：Yuanzheng Cheng Zhuofan Gui Ran Tao You Wang Shaolin Zhu 

机构地区：[1]State Key Laboratory of Coordination Chemistry,Jiangsu Key Laboratory of Advanced Organic Materials,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China [2]Department of Chemistry,New York University,New York 10003,United States

出　　处：《Green Synthesis and Catalysis》2022年第4期377-379,共3页绿色合成与催化（英文）

基　　金：We thank the financial support from the Natural Science Foundation of Jiangsu Province(No.BK20190281).

摘　　要：An enantioselective NiH-catalyzed hydroalkynylation ofα,β-unsaturated amides is reported.A wide range ofα,β-unsaturated amides and bromoalkynes are suitable substrates for this reaction,which proceeds under mild conditions,allowing access to a variety of enantioenriched chiralβ-alkynyl amides.β,γ-Unsaturated amides can also be used as substrates and undergo theβ-selective hydroalkynylation with a slightly lower enantiomeric excess.

关 键 词：ALKENES ALKYNYLATION Asymmetric catalysis NICKEL Nickel-hydride 

分 类 号：O62[理学—有机化学]