Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines  

作　　者：Linlin Shi Tiantian Li Guang-Jian Mei 

机构地区：[1]Green Catalysis Center,and College of Chemistry,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Green Synthesis and Catalysis》2022年第3期227-242,共16页绿色合成与催化（英文）

基　　金：support from the National Natural Science Foundation of China(Grant Nos.22101267);Natural Science Foundation of Henan Province(222300420084);application research plan of key scientific research projects in colleges and universities of Henan Province(22A150056).

摘　　要：Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharma-ceuticals,natural products,material science and organometallics.Due to their significant biological and synthetic value,the construction of imidazo[1,2-a]pyridine scaffolds has been a highly intriguing research topic,and substantial progress had been made in the past decades.In this review,we aim to summarize the current advances in direct C–H functionalization of imidazo[1,2-a]pyridines under transition-metal-free conditions.For the selected examples,we focused on the design and catalytic cycle mechanism,as well as on representative outcomes and applications.

关 键 词：Imidazo[1 2-a]pyridines Transition metal-free Iodo-mediated ORGANOCATALYST Oxidant-mediated Base-mediated CATALYST-FREE 

分 类 号：O62[理学—有机化学]