Poly(lactic acid)-aspirin microspheres prepared via the traditional and improved solvent evaporation methods and its application performances  

作　　者：Xiaolin Pan Mengyuan Gao Yun Wang Yanping He Tian Si Yanlin Sun 

机构地区：[1]School of Chemical Engineering,Kunming University of Science and Technology,Kunming 650504,China

出　　处：《Chinese Journal of Chemical Engineering》2023年第8期194-204,共11页中国化学工程学报（英文版）

基　　金：financially supported by National Natural Science Foundation of China (22068018);Yunnan Ten Thousand Talents Plan Young & Elite Talents Project。

摘　　要：Drug-loaded microspheres are significant for the development of modern pharmaceutical products. It is well known that the taken of aspirin for long-term increases the risk of serious gastrointestinal complications, therefore a controllable delivery of aspirin is of importance to lighten those side effects. In this work, poly(lactic acid)(PLA) was chosen as the carrier to prepare PLA-aspirin microspheres by using the traditional and the improved solvent evaporation methods. It was found that no matter which experimental condition was, the encapsulation efficiency of aspirin was higher by using the improved method than that of the traditional method. Specifically, when the concentration of polyvinyl alcohol = 1%(mass),the polymer concentration = 1:20, the oil/water rate = 1:2.5, PLA-aspirin microspheres were obtained via the improved method with a high yield of 82.83%(mass) and an encapsulation efficiency of 44.09%. PLAaspirin microspheres were then prepared continuously using the improved method, which further enhanced the encapsulation efficiency to 54.56%. Approximate 85% aspirin released from microspheres within 7 days. Obvious degradation which was represented by reduction on hardness was observed by soaking microspheres in PBS for 60 days. This work is of interest because it provides a continuous route to prepare PLA-aspirin microspheres continuously with a high drug encapsulation efficiency.

关 键 词：ASPIRIN Degradation Foam-transfer MICROSPHERES Poly(lactic acid) Slow-release 

分 类 号：TQ460.4[化学工程—制药化工] TQ317