AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1  

作　　者：Jordana B.Freemantle D.Grahame Hardie 

机构地区：[1]Division of Cell Signalling&Immunology,School of Life Sciences,University of Dundee,Dundee,DD15EH,Scotland,United Kingdom

出　　处：《Life Metabolism》2023年第5期2-5,共4页生命（代谢（英文）

基　　金：supported by an Investigator Award from the Wellcome Trust(204766/Z/16/Z).

摘　　要：The AMP-activated protein kinase(AMPK)is known to maintain the integrity of cellular mitochondrial networks by(i)promoting fission,(ii)inhibiting fusion,(iii)promoting recycling of damaged components via mitophagy,(iv)enhancing lysosomal biogenesis to support mitophagy,and(v)promoting biogenesis of new mitochondrial components.While the AMPK targets underlying the first three of these effects are known,a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1(FNIP1)by AMPK may be involved in the remaining two.

关 键 词：MAINTAIN INTERACTING GENESIS 

分 类 号：O57[理学—粒子物理与原子核物理]