Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis  

作　　者：Pei Tang Huijing Wang Wen Zhang Fen-Er Chen 

机构地区：[1]Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Shanghai 200433,China

出　　处：《Green Synthesis and Catalysis》2020年第1期26-41,共16页绿色合成与催化（英文）

基　　金：This work was supported by the Fundamental Research Funds for the Central Universities(YJ201805,YJ201864).

摘　　要：Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral amine structures in organic synthesis.This review focuses on recent applications of asymmetric hydrogenations of imine and enamine substrates in the total syntheses of natural products.These applications include diverse processes involving asymmetric transfer hydrogenation(ATH)and asymmetric hydrogenation(AH)to form key chiral amine motifs in natural products with good efficiency and high-level enantiocontrol.

关 键 词：Asymmetric catalytic hydrogenation Imine substrates Enamine substrates Natural product synthesis Enantioselectivity 

分 类 号：O62[理学—有机化学]