Radical coupling of β-ketoesters and amides promoted by Brønsted/ Lewis acids  

作　　者：Joshua L.Zhu Stephen W.Laws Michael J.Rourke Karl A.Scheidt 

机构地区：[1]Department of Chemistry,Center for Molecular Innovation and Drug Discovery,Northwestern University,Evanston,IL 60208,United States

出　　处：《Green Synthesis and Catalysis》2020年第1期70-74,共5页绿色合成与催化（英文）

基　　金：We thank Northwestern University and the National Institute of General Medical Sciences(Nos.R01 GM131431 and R35 GM136440)for support of this work.

摘　　要：Recent advances in photocatalysis have enabled radical methods with complementary chemoselectivity to established two electron bond forming approaches.While this radical strategy has previously been limited to substrates with favorable redox potentials,Brønsted/Lewis acid activation has emerged as a means of facilitating otherwise difficult reductions.We report herein our investigations into the Lewis acid-promoted redox activation ofβ-ketocarbonyls in a model photocatalytic radical alkylation reaction.Rapid evaluation of substrates and reactions conditions was achieved by high throughput experimentation using 96-well plate photoreactors.

关 键 词：PHOTOCHEMISTRY Lewis acid Catalysis ALKYLATION RADICALS 

分 类 号：O62[理学—有机化学]