Stereoselective fluoroarylation of 1,1-difluoroallenes enabled by palladium catalysis  

作　　者：Huanhuan Luo Yunfei Zhao Dawei Wang Minyan Wang Zhuangzhi Shi 

机构地区：[1]State Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China [2]School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,China

出　　处：《Green Synthesis and Catalysis》2020年第2期134-142,共9页绿色合成与催化（英文）

基　　金：We thank the National Natural Science Foundation of China(Nos.21672097,21901111);the National Natural Science Foundation of Jiangsu Province(No.BK20170632)for their financial support.

摘　　要：A novel protocol for palladium-catalyzed fluoroarylation of 1,1-difluoroallenes was described here.The reaction proceeded smoothly under mild condition and various trifluoromethylated alkenes were obtained in moderate yields with excellent E selectivity.The mechanism involving a vital trifluoromethylated vinyl silver intermediate,which generated through the F-nucleophilic addition to 1,1-difluoroallenes,has been proposed.

关 键 词：ALLENES Fluoroarylation STEREOSELECTIVITY Trifluoromethylated alkenes Palladium catalysis 

分 类 号：O62[理学—有机化学]