Approaches to Nanoparticle Labeling:A Review of Fluorescent,Radiological,and Metallic Techniques  

作　　者：Huilin Chen Qingyuan Hu Wenjie Li Xiaoming Cai Liang Mao Ruibin Li 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Jiangsu 215123,China [2]State Key Laboratory of Pollution Control and Resource Reuse,School of the Environment,Nanjing University,Nanjing 210093,China [3]School of Public Health,Soochow University,Jiangsu 215123,China

出　　处：《Environment & Health》2023年第2期75-89,共15页环境与健康（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.22125602,U2067215,and 22076078).

摘　　要：Nanomaterials are widely used in commercial products,resulting in the release of nanoscale particles into the environment.This raises concerns about their potential exposure risks in complex biological matrices.Most attempts use engineered nanomaterials(ENMs)to mimic the biological behavior of nanoparticles in the environment,and labeling of ENMs by sensors is a commonly used approach for sensitive detection and tracking of ENMs in organisms.However,due to the distinct physicochemical properties of nanoparticles,different labeling approaches have been developed,each with varying applicability.In this Review,we summarize the three main types of labeling methods used for nanoparticles:fluorescent,radiological,and metallic labeling.We discuss their labeling mechanisms,efficiency,stability,target nanoparticles,and applicability in different organism models.Finally,we propose a labeling scheme for specific nanoparticles.Overall,this Review provides a comprehensive overview of the advances in nanoparticle labeling techniques and their potential applications in environmental and health studies.

关 键 词：Imaging NANOBIOLOGY NANOTOXICITY Detection Analysis 

分 类 号：TB383.1[一般工业技术—材料科学与工程]