Ambient Nitrogen Dioxide and Hospitalizations of Full-Spectrum Respiratory Diseases:A National Case-Crossover Study  

作　　者：Cong Liu Renjie Chen Jian Lei Yixiang Zhu Lu Zhou Xia Meng Jianwei Xuan Haidong Kan 

机构地区：[1]School of Public Health,Key Lab of Public Health Safety of the Ministry of Education,NHC Key Lab of Health Technology Assessment,IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health,Fudan University,Shanghai 200032,China

出　　处：《Environment & Health》2023年第2期130-138,共9页环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.92043301,82103790);the Shanghai International Science and Technology Partnership Project(Grant No.21230780200).

摘　　要：Few multicity studies have examined the acute effects of nitrogen dioxide(NO_(2))on respiratory disease(RD),especially its specific causes.This study aimed to investigate the associations between short-term exposure to NO_(2)and hospitalization of full-spectrum RDs in China.Hospitalization of 10 major categories and 40 cause-specific RDs were obtained from 20 provinces over the study period of 2013−2020.A time-stratified case-crossover study was conducted at the individual level to explore the associations between NO_(2)and RDs.NO_(2)was significantly associated with increased hospitalization of eight major RDs(acute upper respiratory infections,influenza and pneumonia,acute lower respiratory infections,upper respiratory tract diseases,chronic lower respiratory diseases,respiratory interstitium diseases,pleura diseases,and other respiratory diseases)and 18 specific causes of RDs,with the largest associations observed on lag 0−1 day.The effect estimates ranged from 0.75 to 4.09%per 10μg/m^(3)of NO_(2)exposure.The associations remained robust after controlling for copollutants.The concentration−response curves were mostly positive and linear.This nationwide study provides comprehensive information on the acute effects of NO_(2)on respiratory morbidity across the full spectrum,highlighting the need for caution with regard to this important traffic-related air pollutant in current pollution control programs.

关 键 词：nitrogen dioxide respiratory disease HOSPITALIZATION cause-specific case-crossover study 

分 类 号：R56[医药卫生—呼吸系统]