桑菊饮加减合银翘散治疗流感病毒感染外感发热的临床研究  

Clinical Study on the Treatment of Exogenous Fever Caused by Influenza Virus Infection with Sangju Drink plus Yinqiao Powder

作　　者：刘旭凌[1] 李季[1] 邵周俊 周璇 樊琴[1] 薛冬英[1] Liu Xuling;Li Ji;Shao Zhoujun;Zhou Xuan;Fan Qin;Xue Dongying(Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属普陀医院,上海200062

出　　处：《中国中医急症》2023年第10期1733-1736,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市中医药管理局传染病中医药防治能力建设项目(ZYYB-FRMZ-06)。

摘　　要：目的 观察桑菊饮加减合银翘散对流感病毒感染外感发热患者的临床疗效。方法 289例流感病毒感染患者按随机数字表法分为对照组与研究组,对照组采用常规流感治疗方案,研究组在常规流感治疗方案的基础上服用桑菊饮加减合银翘散,两组患者均连续治疗5 d。治疗结束后统计病例研究完成情况和临床疗效,对比两组患者退热时间、止咳时间、痰液中抗/促炎细胞因子含量以及唾液中分泌型免疫球蛋白A(sIgA)并计算sIgA和血清白蛋白(ALB)的比值sIgA/ALB。结果 治疗后研究组中医症状积分明显低于对照组(P <0.05),研究组显效率为96.40%,明显高于对照组的89.71%(P <0.05),研究组退热时间和止咳时间均明显短于对照组(P <0.05),治疗后研究组促炎因子白细胞介素-17(IL-17)含量明显低于对照组(P <0.05),抗炎因子干扰素(IFN-g)、白细胞介素-10(IL-10)含量明显高于对照组(P <0.05),治疗后研究组唾液sIgA含量和sIgA/ALB水平明显高于对照组(P <0.05)。结论 桑菊饮加减合银翘散对流感病毒感染外感发热患者临床疗效较好,有助于快速退热和止咳,调节机体炎症水平,同时改善呼吸道黏膜免疫屏障功能。Objective:To investigate the effect of Sangju Drink plus Yinqiao Powder on patients with influenza virus infection and exothermic fever.Methods:A total of 289 patients with influenza virus infection were divided into a control group and a study group according to random number table method.The control group adopted the conventional influenza treatment scheme,and the study group took Sangju Drink plus Yinqiao Powder on the basis of the conventional influenza treatment scheme.Both groups were treated continuously for 5 days.After the treatment,the completion of the case study and the clinical efficacy were counted.The antipyretic time,cough stopping time,the content of anti/proinflammatory cytokines in sputum and the immunoglobulin A(sIgA)in saliva were compared between the two groups,and the ratio of sIgA to serum albumin(ALB),sIgA/ALB,was calculated.Results:After treatment,the TCM symptom score of the study group was significantly lower than that of the control group(P<0.05).The effective rate of the study group was 96.40%,which was significantly higher than 89.71% of the control group(P<0.05).The antipyretic time and cough stopping time of the study group were significantly shorter than that of the control group(P<0.05).After treatment,the content of proinflammatory factor IL-17 in the study group was significantly lower than that of the control group(P<0.05),and the content of anti-inflammatory factors IFN-g and IL-10 was significantly higher than that of the control group(P<0.05),After treatment,the salivary sIgA content and s IgA/ALB level in the study group were significantly higher than those in the control group(P<0.05).Conclusion:Sangju Drink plus Yinqiao Powder has a good clinical effect on patients with influenza virus infection and exothermic fever.It is helpful to rapidly reduce fever and cough,regulate the level of body inflammation,and improve the immune barrier function of respiratory mucosa.

关 键 词：流行性感冒 发热 桑菊饮 银翘散 止咳 炎性反应 呼吸道黏膜免疫屏障 

分 类 号：R511[医药卫生—内科学]