ICU危重症中医虚实证型与血清胱抑素C、载脂蛋白、SIL-2R水平的关系  

Relationship between TCM Deficiency and Excess Syndrome Types and Levels of Serum CysC,Apolipoprotein and SIL-2R in ICU Critical Illness

作　　者：柯海霞 张娇珍 蒙夏玲 许政衡 龙邦盛 Ke Haixia;Zhang Jiaozhen;Meng Xialing;Xu Zhengheng;Long Bangsheng(Haikou Hospital of Traditional Chinese Medicine,Hainan,Haikou 570216,China.)

机构地区：[1]海南省海口市中医医院,海南海口570216

出　　处：《中国中医急症》2023年第10期1782-1785,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：海南省自然科学基金面上项目(821MS158)。

摘　　要：目的 探究重症加强护理病房(ICU)危重症中医虚实证型与血清胱抑素C(CysC)、载脂蛋白、可溶性白介素-2受体(SIL-2R)水平的关系。方法 以72例ICU危重症患者为ICU组58例,健康体检者为对照组,比较两组血清CysC、载脂蛋白、SIL-2R水平。根据ICU危重症患者中医证型将其分为实证组、虚证组及虚实并重证组,分析血清CysC、载脂蛋白、SIL-2R水平联合检测对实证、虚证及虚实并重证的鉴别价值。结果 ICU组血清CysC、ApoB100及SIL-2R水平高于对照组,ApoA1水平低于对照组(P <0.05)。实证组、虚证组及虚实并重证组的血清CysC、载脂蛋白、SIL-2R水平对比,差异有统计学意义(P <0.05);实证组的CysC、ApoA1、ApoB100水平高于虚证组,SIL-2R水平低于虚证组,ApoA1、ApoB100及SIL-2R水平低于虚实并重证(P <0.05);虚证组CysC、ApoA1、ApoB100及SIL-2R水平低于虚实并重证(P <0.05)。各指标联合检测鉴别虚证及实证的AUC值均高于血清CysC、载脂蛋白、SIL-2R水平单独检测(P <0.05);各指标联合检测鉴别虚证及实证与虚实并重证的AUC值均高于血清CysC、载脂蛋白、SIL-2R水平单独检测(P <0.05)。结论 实证、虚证及虚实并重证危重症患者的血清CysC、载脂蛋白、SIL-2R水平存在差异,且各血清指标联合检测对虚实证具有鉴别价值。Objective:To explore the relationship between TCM deficiency and excess syndrome types and lev⁃els of serum cystatin C(CysC),apolipoprotein and soluble interleukin-2 receptor(SIL-2R)in critically ill patients in intensive care unit(ICU).Methods:A total of 72 critically ill patients in ICU and 58 healthy subjects with physical examination were enrolled as the study subjects.Serum levels of CysC,apolipoprotein and SIL-2R were compared between the two groups.ICU critically ill patients were divided into excess syndrome group,deficiency syndrome group and deficiency-excess syndrome group according to the TCM syndrome types.The identification value of combined detection of serum CysC,apolipoprotein and SIL-2R on excess syndrome,deficiency syndrome and deficiency-excess syndrome was analyzed.Results:The levels of serum CysC,ApoB100 and SIL-2R in ICU group were higher than those in the control group,while the level of ApoA1 was lower than that in the control group(P<0.05).The differences in serum levels of CysC,apolipoprotein and SIL-2R were statistically significant among excess syndrome group,deficiency syndrome group and deficiency-excess syndrome group(P<0.05).The levels of CysC,ApoA1 and ApoB100 in the excess syndrome group were higher than those in the deficiency syn⁃drome group,while the level of SIL-2R was lower than that in the deficiency syndrome group,and the levels of ApoA1,ApoB100 and SIL-2R were lower than those in the deficiency-excess syndrome group(P<0.05).The lev⁃els of CysC,ApoA1,ApoB100 and SIL-2R in the deficiency syndrome group were lower than those in the deficien⁃cy-excess syndrome group(P<0.05).The AUC values of combined detection of all indicators in identifying defi⁃ciency syndrome and excess syndrome were higher than those of serum CysC,apolipoprotein or SIL2R alone(P<0.05).The AUC values of combined detection of all indicators in identifying deficiency syndrome or excess syn⁃drome with deficiency-excess syndrome were higher than those of serum CysC,apolipoprotein or SIL-2R alone(

关 键 词：ICU 危重症 中医虚实证型 胱抑素C 载脂蛋白 可溶性白介素-2受体 

分 类 号：R241[医药卫生—中医诊断学]