基于数据挖掘的泻心汤类方应用特点及用药规律分析  

Application Characteristics and Medication Regularity of Xiexin Decoction (泻心汤) and Related Formulas Based on Data Mining

作　　者：袁晞钒 雷会霞 苗明三[1] YUAN Xifan;LEI Huixia;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中药药理与临床》2023年第9期95-100,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(编号:80274038);河南省重大公益专项(编号:201300310100);河南省药品监督管理局科技计划项目(编号:2020DB050-55、2020DB134-49);河南省科学技术厅科技攻关(编号:212102310351);河南省中医药科学研究专项课(编号:20-21ZYZD02)。

摘　　要：目的:基于数据挖掘泻心汤类方的应用特点及用药规律分析,为今后的泻心汤类方应用提供新的思路。方法:以中国知网、万方数据库、维普、中国生物医学文献数据库、SinoMed、等为数据来源,“半夏泻心汤”“甘草泻心汤”“生姜泻心汤”“大黄黄连泻心汤”“附子泻心汤”为“主题”词,并锁定“应用”在“全文”中进行专业检索,选择泻心汤类方应用的临床研究文献录入Excel 2019中,再利用SPSS Statistics 25.0、SPSS Clementine12.0软件对数据进行聚类分析和关联规则分析。结果:纳入文献532篇,方剂659首及198个单味药,涉及泻心汤类方中医主治病证3个种类,共46种,现代医学主治病证59种,主治最优势病证是脾胃类疾病,即消化系统疾病;单味高频药分别是黄连(593次,89.98%)、黄芩(549次,83.30%)、干姜(536次,81.33%)、半夏(490次,74.35%)、大枣(417次,63.27%)、党参(373次,56.60%)、甘草(296次,44.91%),单味高频药物的用量范围分别为黄连(5 g~10 g)、黄芩(5 g~10 g)、干姜(5 g~10 g)、半夏(10 g~15 g)、大枣(4枚~12枚)、党参(10 g~20 g)、甘草(6 g~10 g);高频药药性居前2位依次是温性(8次,32%)、寒性(5次,20%);单味药中频数位居前2位的依次是苦味(14次,35.89%)、辛味(11次,28.20%);聚类分析中高频单味药分为3类。结论:泻心汤类方中药物多为补虚、清热、理气、温里药,性味多苦寒,临床主要治疗脾胃类疾病,除此之外还涉及内科、妇科等多种类型的疾病,为临床泻心汤类方配伍及其临床应用提供参考。Objective:To analyze the application characteristics and medication regularity of Xiexin Decoction(泻心汤)and related formulas by data mining and provide new ideas for the application of Xiexin Decoction and related formulas in the future.Methods:The clinical research articles on the application of Xiexin Decoction and related formulas were retrieved from CNKI,Wanfang Data,VIP,CBMdisc,SinoMed,etc.with the terms"Banxia Xiexin Decoction"(半夏泻心汤),"Gancao Xiexin Decoction"(甘草泻心汤),"Shengjiang Xiexin Decoction"(生姜泻心汤),"Dahuang Huanglian Xiexin Decoction"(大黄黄连泻心汤),and"Fuzi Xiexin Decoction"(附子泻心汤)and input into Excel 2019.SPSS Statistics 25.0 and SPSS Clementine12.0 were used for cluster analysis and association rule analysis.Results:A total of 532 articles containing 659 prescriptions and 198 single drugs were included,involving 46 traditional Chinese medicine(TCM)indications of Xiexin Decoction in three categories and 59 modern medicine indications.The top dominant diseases were the spleen and stomach diseases,namely digestive system diseases.The high-frequency drugs were COPTIDIS RHIZOMA(n=593,89.98%),SCUTELLARIAE RADIX(n=549,83.30%),ZINGIBERIS RHIZOMA(n=536,81.33%),PINELLIAE RHIZOMA(n=490,74.35%),JUJUBAE FRUCTUS(n=417,63.27%),CODONOPSIS RADIX(n=373,56.60%),and GLYCYRRHIZAE RADIX ET RHIZOMA(n=296,44.91%).The dosage ranges of high-frequency drugs were listed below:COPTIDIS RHIZOMA(5 g~10 g),SCUTELLARIAE RADIX(5 g~10 g),ZINGIBERIS RHIZOMA(5 g~10 g),PINELLIAE RHIZOMA(10 g~15 g),JUJUBAE FRUCTUS(4~12),CODONOPSIS RADIX(10 g~20 g),and GLYCYRRHIZAE RADIX ET RHIZOMA(6 g~10 g).The top 2 Yaoxing(药性)of high-frequency drugs were Wen(温)(n=8,32%)and Han(寒)(n=5,20%).The top 2 Yaowei(药味)of single drugs were Ku(苦)(n=14,35.89%)and Xin(辛)(n=11,28.20%).As revealed by the cluster analysis,high-frequency drugs were divided into three categories.Conclusion:The drugs in Xiexin Decoction and related formulas were mainly effective in Buxu(补虚),Qingre(清热),Liqi(理�

关 键 词：泻心汤类方 应用特点 数据挖掘 用药规律 

分 类 号：R289.5[医药卫生—方剂学]