血清MAL蛋白水平和急性冠状动脉综合征的相关性研究  

Study on the correlation between serum MAL protein level and acute coronary syndrome

作　　者：胡擎天 王月祥 曾超超 李静 耿志军 刘进军[1] HU Qing-tian;WANG Yue-xiang;ZENG Chao-chao;LI Jing;GENG Zhi-jun;LIU Jin-jun(Department of Cardiology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China;Department of Medical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China;Department of Central Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院心血管科,安徽蚌埠233004 [2]蚌埠医学院第一附属医院检验科,安徽蚌埠233004 [3]蚌埠医学院第一附属医院中心实验室,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2023年第10期1383-1386,共4页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点项目(KJ2018A0219)。

摘　　要：目的:探讨血清MAL蛋白水平与急性冠状动脉综合征(ACS)及其冠状动脉病变严重程度的相关性。方法:选择确诊为ACS病人122例作为研究对象,并进一步分为急性心肌梗死组60例和不稳定型心绞痛组62例,并选取冠状动脉造影未见异常的受试者60名作为对照组。采用ELISA检测各组血清MAL蛋白水平;分析各组间血清MAL蛋白水平差异及临床意义;采用Gensini评分协助评估MAL蛋白水平和ACS血管病变程度的相关性。结果:AMI组和UA组的血清MAL蛋白水平均显著高于对照组(P<0.01),而UA组与AMI组差异无统计学意义(P>0.05)。UA组和AMI组血清MAL蛋白水平和Gensini评分均无明显相关性(P>0.05)。血清MAL蛋白水平诊断ACS具有一定的诊断参考价值;血清MAL蛋白诊断AMI的AUC为0.863,95%CI为0.794~0.932,诊断UA的AUC为0.768,95%CI为0.684~0.852。结论:ACS病人血清MAL蛋白水平显著高于冠状动脉造影正常的人群,该蛋白未来可能有助于ACS的诊断。Objective:To study the relationship between MAL protein and acute coronary syndrome(ACS)and the severity of coronary arteries.Methods:A total of 122 patients diagnosed as ACS were selected as the study group,and then divided into subgroups:acute myocardial infraction(AMI)group,including 60 patients;unstable angina(UA)group,including 62 patients.Patients who underwent coronary angiography that without markable coronary artery straitness were selected as control group.ELISA was used to evaluate the MAL protein of each group.The clinical significance and difference of MAL protein between groups were evaluated.Gensini score was used to evaluate the relationships between MAL protein and the straitness of acute coronary disease.Results:The level of serum MAL protein in AMI group and UA group was significantly higher than that in control group(P<0.01),but there was no significant difference between UA group and AMI group(P>0.05).There was no significant correlation between serum MAL protein level and Gensini score in UA group and AMI group(P>0.05).Serum MAL protein level had a certain diagnostic reference value in the diagnosis of ACS.AUC of serum MAL protein for AMI was 0.863,95%CI was 0.794-0.932,and AUC for UA was 0.768,95%CI was 0.684-0.852.Conclusions:Serum MAL protein level in ACS patients is notably higher than that in people with with a normal coronary angiography result.The protein may be useful for the diagnosis of ACS in the future.

关 键 词：急性冠状动脉综合征 冠状动脉粥样硬化性心脏病 MAL蛋白 急性心肌梗死 不稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]