乌司他丁联合血液透析治疗肾综合出血热的临床疗效  

Clinical effect of ulinastatin combined with hemodialysis in the treatment of hemorrhagic fever with renal syndrome

作　　者：张建锐 许振东[2] ZHANG Jianrui;XU Zhendong(Department of Infectious Diseases,People's Hospital of Pingdu City,Qingdao,Shandong,266700,China;The Second Department of Neurosurgery,Pingdu People's Hospital,Qingdao,Shandong,266700,China)

机构地区：[1]平度市人民医院感染科,山东青岛266700 [2]平度市人民医院神经外二科,山东青岛266700

出　　处：《当代医学》2023年第23期4-7,共4页Contemporary Medicine

摘　　要：目的探究乌司他丁联合血液透析治疗肾综合出血热的临床疗效。方法选取2017年2月至2019年2月本院收治的78例肾综合出血热患者作为研究对象,根据治疗方式不同分为对照组与观察组,各39例。对照组予以血液透析治疗,观察组在对照组基础上予以乌司他丁辅助治疗,比较两组治疗前后血浆内皮素、循环内皮细胞量、血清肌酐水平、急性肾衰竭(ARF)相关因子[血清可溶性细胞黏附因子-1(sICAM-1)、L-选择素(L-sel)、E选择素(E-sel)]水平及不良反应发生情况。结果治疗后,两组血浆内皮素、循环内皮细胞量及血清肌酐水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组sICAM-1、L-sel、E-sel水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义。结论乌司他丁联合血液透析治疗肾综合出血热疗效显著,可抑制患者炎症因子表达,促进肾功能转归,且安全性高,值得临床推广应用。Objective To explore the clinical efficacy of ulinastatin combined with hemodialysis in the treatment of hemorrhagic fever with renal syndrome.Methods A total of 78 patients with hemorrhagic fever with renal syndrome admitted to our hospital from February 2017 to February 2019 were selected as the study subjects,and they were divided into the control group and the observation group according to different treatment methods,with 39 cases in each group.The control group received hemodialysis for treatment,the observation group was given adjuvant treatment with ulinastatin on the basis of the control group,the plasma endothelin,circulating endothelial cell volume,serum creatinine level,acute renal failure(ARF)related factors(serum soluble cell adhesion factor-1[sICAM-1],L-selectin[L-sel],E-sel[E-sel])levels and the incidence of adverse reactions were compared between two groups.Results After treatment,the levels of plasma endothelin,circulating endothelial cells and serum creatinine levels of the two groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of sICAM-1,L-sel and E-sel of two groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reaction between the two groups.Conclusion Ulinastatin combined with hemodialysis in the treatment of hemorrhagic fever with renal syndrome is effective,can inhibit the expression of inflammatory factors,promote the outcome of renal function,and has high safe,it is worthy of clinical promotion and application.

关 键 词：乌司他丁 血液透析 肾综合出血热 肾功能 不良反应 

分 类 号：R692.5[医药卫生—泌尿科学]