布地奈德联合孟鲁司特钠片治疗对喘息性肺炎患儿血清降钙素原及C反应蛋白的影响  

Effect of budesonide combined with montelukast table on serum procalcitonin and C-reactive protein in children with asthmatic pneumonia

作　　者：张莎莎 应艳花 朱橙 ZHANG Shasha;YING Yanhua;ZHU Cheng(Department of Pediatrics,the Third People's Hospital of Pingxiang City,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市第三人民医院儿科,江西萍乡337000

出　　处：《当代医学》2023年第23期24-27,共4页Contemporary Medicine

摘　　要：目的探究布地奈德联合孟鲁司特钠片治疗对喘息性肺炎患儿血清降钙素原(PCT)及C反应蛋白(CRP)的影响。方法选取2021年3—12月萍乡市第三人民医院儿科收治的50例喘息性肺炎患儿作为研究对象,按照随机数字表法分为联合组与常规组,各25例。常规组给予对症、抗感染联合布地奈德治疗,联合组在常规组基础上联合孟鲁司特钠片治疗,比较两组临床疗效、临床症状消失时间(咳嗽、呼吸困难以及喘息)、治疗前后血清PCT与CRP水平、血常规指标[WBC、中性粒细胞(NEUT)]、治疗期间并发症发生情况及复发率。结果治疗后,联合组治疗总有效率(96.00%)明显高于常规组(68.00%),差异有统计学意义(P<0.05)。联合组咳嗽、呼吸困难及喘息消失时间均显著短于常规组,差异有统计学意义(P<0.05)。治疗后,两组血清PCT、CRP水平均低于治疗前,且联合组低于常规组,差异有统计学意义(P<0.05)。治疗后,两组WBC、NEUT水平均低于治疗前,且联合组低于常规组,差异有统计学意义(P<0.05)。联合组不良反应发生率(16.00%)与常规组(12.00%)比较差异无统计学意义。联合组治疗后6个月和1年时复发率(0.00%、8.00%)均明显低于常规组(24.00%、36.00%),差异有统计学意义(P<0.05)。结论采用布地奈德联合孟鲁司特钠片治疗喘息性肺炎患儿疗效显著,能加快患儿康复进程,降低PCT、CRP水平,缓解患儿感染情况,并降低治疗后复发率,安全性较高,值得临床推广应用。Objective To explore the effect of budesonide combined with montelukast table on serum procalcitonin(PCT)and C-reactive protein(CRP)in children with asthmatic pneumonia.Methods 50 children with asthmatic pneumonia admitted to department of Pediatrics of the Third People's Hospital of Pingxiang City from March 2021 to December 2021 were selected as the study subjects,and they were divided into the combined group and the conventional group according to random number table method,with 25 cases in each group.The conventional group was treated with symptomatic treatment and anti-infection combined with budesonide,and the combined group was given montelukast table on the basis of the conventional group,the clinical efficacy,disappearance times of clinical symptoms(cough,dyspnea and wheezing),serum PCT and CRP levels and blood routine indicators(WBC,neutrophil[NEUT])before and after treatment and occurrence of complications and recurrence rate during treatment were compared between the two groups.Results After treatment,the total effective rate of treatment in the combined group(96.00%)was significantly higher than that in the conventional group(68.00%),the difference was statistically significant(P<0.05).The disappearance times of cough,dyspnea and wheezing in the combined group were significantly shorter than those in the conventional group,the differences were statistically significant(P<0.05).After treatment,the levels of serum PCT and CRP of the two groups were lower than those before treatment,and the combined group were lower than the conventional group,the differences were statistically significant(P<0.05).After treatment,the WBC and NEUT levels of the two groups were lower than those before treatment,and the combined group were lower than the conventional group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the combined group(16.00%)and the conventional group(12.00%).The recurrence rates at 6 months and

关 键 词：儿童喘息性肺炎 布地奈德 孟鲁司特钠片 降钙素原 C反应蛋白 

分 类 号：R725.6[医药卫生—儿科]