持续皮下注射胰岛素治疗糖尿病合并甲状腺功能亢进的临床应用  

Clinical application of continuous subcutaneous injection of insulin in the treatment of diabetes mellitus complicated with hyperthyroidism

作　　者：刘芳薇 袁景[1] 鲁丽[1] LIU Fangwei;YUAN Jing;LU Li(Department of Endocrinology,Liaoning Provincial People's Hospital,Shenyang,Liaoning,110016,China)

机构地区：[1]辽宁省人民医院内分泌科,辽宁沈阳110016

出　　处：《当代医学》2023年第23期84-87,共4页Contemporary Medicine

摘　　要：目的探讨持续皮下注射胰岛素治疗糖尿病合并甲状腺功能亢进的临床应用。方法选取2018年2月至2021年4月辽宁省人民医院收治的86例糖尿病合并甲状腺功能亢进患者作为研究对象,随机分为持续组与参照组,每组43例。持续组持续皮下注射胰岛素,参照组多次皮下注射胰岛素,比较两组并发症发生率、用药前后血糖与甲状腺指标及临床疗效。结果用药后,两组餐后2 h血糖(2 h PG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平均低于用药前,且持续组低于参照组,差异有统计学意义(P<0.05)。用药后,两组促甲状腺激素(TSH)高于用药前,游离三碘甲腺原氨酸(FT_(3))、总三碘甲状腺原氨酸(TT_(3))水平均低于用药前,且持续组TSH水平高于参照组,FT_(3)、TT_(3)水平均低于参照组,差异有统计学意义(P<0.05)。持续组并发症发生率低于参照组,治疗总有效率高于参照组,差异有统计学意义(P<0.05)。结论持续皮下注射胰岛素治疗糖尿病合并甲状腺功能亢进患者疗效确切,可发挥良好的降糖作用,有效促进患者甲状腺功能恢复,降低相关并发症发生风险,提高治疗安全性,值得临床推广应用。Objective To explore the clinical application of continuous subcutaneous injection of insulin on diabetes mellitus complicated with hyperthyroidism.Methods 86 patients with diabetes mellitus complicated with hyperthyroidism in Liaoning Provincial People's Hospital from February 2018 to April 2021 were selected as the research subjects,and they were divided into the continuous group and the reference group according to double-blind grouping method,with 43 cases in each group.The continuous group received continuous subcutaneous insulin injection,while the reference group received multiple subcutaneous insulin injections,the incidence of complications,blood glucose and thyroid index before and after medication and clinical efficacy were compared between the two groups.Results After taking the medicine,the postprandial 2 h blood glucose(2 h PG),fasting blood glucose(FPG)and glycosylated hemoglobin(HbA1c)levels of the two groups were lower than before taking the medicine,and the continuous group was lower than the reference group,and the difference was statistically significant(P<0.05).After aking the medication,TSH levels of the two groups was higher than before medication,while free triiodothyronine(FT_(3))and total triiodothyronine(TT_(3))levels were lower than those before medication,and TSH levels in the continuous group was higher than that in the reference group,while FT_(3) and TT_(3) levels were lower than that in the reference group,and the differences were statistically significant(P<0.05).The incidence of complications in the continuous group was lower than that in the reference group,and the effective rate was higher than that in the reference group,and the differences were statistically significant(P<0.05).Conclusion Continuous subcutaneous injection of insulin in the treatment of diabetic patients with hyperthyroidism has definite efficacy,can play a good hypoglycemic effect,effectively promote the recovery of thyroid function in patients,reduce the risk of related complications,and improve treatment s

关 键 词：胰岛素 甲亢 糖尿病 临床应用 

分 类 号：R587.2[医药卫生—内分泌] R581.1[医药卫生—内科学]