改良乳突根治术联合开放式鼓室成形术对化脓性中耳炎患者气导听阈和外耳道形状及炎症因子的影响  

Effects of modified radical mastoidectomy combined with open tympanoplasty on airway threshold,external auditory canal shape and inflammatory factors in patients with suppurative otitis media

作　　者：苏贵红 高岩 卢红梅 SU Guihong;GAO Yan;LU Hongmei(Physical Examination Center,the First People's Hospital of Jinzhou District,Dalian,Liaoning,116100,China)

机构地区：[1]大连市金州区第一人民医院体检中心,辽宁大连116100

出　　处：《当代医学》2023年第23期168-171,共4页Contemporary Medicine

摘　　要：目的探讨改良乳突根治联合开放式鼓室成形术对化脓性中耳炎(SOM)患者气导听阈、外耳道形状及炎症因子影响。方法选取本院2017年9月至2019年10月收治的92例SOM患者作为研究对象,随机分为实验组与对照组,每组46例。实验组采用改良乳突根治术联合开放式鼓室成形术,对照组采用改良乳突根治术,比较两组气导听阈值、外耳道形状变化,白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)水平。结果术前,两组气导听阈值比较差异无统计学意义;手术后,两组气导听阈值低于术前,且实验组低于对照组,差异有统计学意义(P<0.05)。术后,实验组外耳道形状变化优于较对照组,差异有统计学意义(P<0.05)。术前,两组IL-8、IL-1β、TNF-α水平比较差异无统计学意义;术后,两组IL-8、IL-1β、TNF-α水平均低于术前,且实验组低于对照组,差异有统计学意义(P<0.05)。结论改良乳突根治术联合开放式鼓室成形术有助于减轻SOM患者炎症反应,改善外耳道形状,降低其气导听阈值,值得临床推广应用。Objective To investigate the effects of modified radical mastoidectomy combined with open tympanoplasty on airway threshold,external auditory canal shape and inflammatory factors in patients with suppurative otitis media(SOM).Methods A total of 92 SOM patients admitted to our hospital from September 2017 to October 2019 were selected as research subjects,and they were randomly divided into the experimental group and the control group,with 46 cases in each group.The experimental group underwent modified radical mastoidectomy combined with open tympanoplasty,and the control group underwent modified radical mastoidectomy.The threshold of air conduction,external auditory canal shape change,interleukin-8(IL-8),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)levels were compared between the two groups.Results Before operation,there was no significant difference in threshold of air conduction between the two groups;after operation,the threshold of air conduction of the two groups was lower than before operation,and the experimental group was lower than taht in the control group,the difference was statistically significant(P<0.05).After operation,the external auditory canal shape change in the experimental group was better than that in the control group,and the difference was statistically significant(P<0.05).Before operation,there were no significant differences in IL-8,IL-1βand TNF-αlevels between the two groups;after operation,IL-8,IL-1βand TNF-αlevels of the two groups were lower than those before operation,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion Modified radical mastoidectomy combined with open tympanoplasty can reduce inflammation,improve the shape of the external auditory canal and lower threshold of air conduction in SOM patients,which is worthy of clinical promotion and application.

关 键 词：化脓性中耳炎 开放式鼓室成形术 改良乳突根治术 外耳道形状 炎症因子 

分 类 号：R764.9[医药卫生—耳鼻咽喉科]