经鼻高流量氧疗与成比例辅助通气治疗急性左心衰竭疗效对比及NT-proBNP、MR-proANP的差异性表达  

HFNC VS.PAV in Treating ALHF:Efficacy and NT-proBNP/MR-proANP Expression

作　　者：陈高亮 林建华[1] 林琳[1] CHEN Gao-liang;LIN Jian-hua;LIN Lin(Department of Cardiology,Affiliated Fuqing City Hospital of Fujian Medical University,Fujian Fuqing 350300)

机构地区：[1]福建医科大学附属福清市医院心内科,福建福清350300

出　　处：《中国医疗器械信息》2023年第19期137-139,共3页China Medical Device Information

摘　　要：目的:探讨经鼻高流量氧疗(HFNC)与成比例辅助通气(PAV)治疗急性左心衰竭(ALHF)的临床疗效及其对心肌损伤标志物氨基末端脑钠肽前体(NT-proBNP)和心房钠尿肽前体中肽段(MR-proANP)的影响。方法:共纳入80例ALHF患者,随机分为HFNC组和PAV组,每组40例。结果:HFNC组的临床有效率显著高于PAV组(P<0.05)。HFNC组治疗后24h的心率、呼吸频率、平均动脉压、动脉血二氧化碳分压、心肌做功指数均显著低于PAV组,而动脉血氧分压和左心室射血分数均显著高于PAV组(P<0.05)。HFNC组的气管插管率显著低于PAV组(P<0.05)。HFNC组入院前后及治疗后24h的NT-proBNP和MR-proANP水平均显著低于PAV组(P<0.05)。结论:与PAV相比,HFNC对ALHF患者具有更好的临床疗效,能够改善呼吸功能、心功能和氧合状态,降低气管插管率,减轻心肌损伤,降低NT-proBNP和MR-proANP水平。Objective:Compare high-flow nasal cannula(HFNC)vs.proportional assist ventilation(PAV)in treating acute left heart failure(ALHF)and their impact on NT-proBNP and MR-proANP markers.Methods:A total of 80 patients with ALHF were included and randomly divided into HFNC group and PAV group,with 40 cases in each group.Results:The clinical effective rate of the HFNC group was significantly higher than that of the PAV group(P<0.05).The heart rate,respiratory rate,mean arterial pressure,arterial carbon dioxide partial pressure,and myocardial work index of the HFNC group were significantly lower than those of the PAV group 24 hours after treatment,while arterial oxygen partial pressure and left ventricular ejection fraction were significantly higher than those of the PAV group(P<0.05).Conclusion:Compared with PAV,HFNC has better clinical efficacy in patients with ALHF,improving respiratory function,cardiac function,and oxygenation status,reducing tracheal intubation rate,alleviating myocardial injury,and lowering NT-proBNP and MR-proANP levels.

关 键 词：经鼻高流量氧疗 成比例辅助通气 急性左心衰竭 氨基末端脑钠肽前体 心房钠尿肽前体中肽段 

分 类 号：TH778[机械工程—仪器科学与技术]