拉贝洛尔联合硫酸镁治疗重度妊娠期高血压疾病的临床疗效  

Clinical efficacy of labetalol combined with magnesium sulfate on severe pregnancy-induced hypertension

作　　者：赵碧辉 ZHAO Bi-hui(Xiangtan Central Hospital,Xiangtan 411100,China)

机构地区：[1]湘潭市中心医院妇产科,411100

出　　处：《中国现代药物应用》2023年第19期7-12,共6页Chinese Journal of Modern Drug Application

摘　　要：目的探讨拉贝洛尔联合硫酸镁治疗重度妊娠期高血压疾病的临床疗效。方法100例重度妊娠期高血压疾病患者,随机分为对照组与观察组,每组50例。对照组单用硫酸镁治疗,观察组使用拉贝洛尔联合硫酸镁治疗。比较两组的临床疗效、各项临床指标[收缩压(SBP)、舒张压(DBP)、24 h尿蛋白定量、心率(HR)、胎心率]、不良妊娠结局发生情况、血液流变学指标[纤维蛋白原(FIB)、血浆粘度(PV)、全血低切粘度(LBV)、全血高切粘度(HBV)]、血清因子[C反应蛋白(CRP)、同型半胱氨酸(Hcy)、丙二醛(MDA)、髓过氧化物酶(MPO)、内皮素-1(ET-1)、一氧化氮(NO)、超氧化物歧化酶(SOD)、胎盘生长因子(PLGF)]水平。结果观察组治疗总有效率为94.00%,明显高于对照组的74.00%,差异有统计学意义(P<0.05)。治疗后,观察组SBP(133.72±9.81)mm Hg(1 mm Hg=0.133 kPa)、DBP(85.16±6.30)mm Hg、24 h尿蛋白定量(1.81±0.57)g/24 h明显低于对照组的(146.59±10.67)mm Hg、(94.73±7.08)mm Hg、(2.64±0.72)g/24 h,差异有统计学意义(P<0.05);两组治疗后HR、胎心率比较,差异无统计学意义(P>0.05)。观察组产妇及围生儿不良妊娠结局发生率分别为10.00%、6.00%,均低于对照组的26.00%、22.00%,差异有统计学意义(P<0.05)。治疗后,观察组FIB、PV、LBV、HBV水平分别为(2.32±0.41)g/L、(1.27±0.17)mPa·s、(7.52±0.83)mPa·s、(3.72±0.38)mPa·s,均低于对照组的(3.76±0.64)g/L、(1.50±0.22)mPa·s、(8.80±1.05)mPa·s、(4.29±0.43)mPa·s,差异有统计学意义(P<0.05)。治疗后,观察组CRP、Hcy、MDA、MPO、ET-1水平明显低于对照组,NO、SOD、PLGF水平明显高于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗重度妊娠期高血压疾病的临床疗效显著,血压控制效果好,能降低血液粘稠度,抑制血液高凝状态,减轻炎症及氧化应激反应,改善血管内皮功能,从而减少不良妊娠结局,保障母婴安全。Objective To discuss the clinical efficacy of labetalol combined with magnesium sulfate on severe pregnancy-induced hypertension.Methods A total of 100 patients with severe pregnancy-induced hypertension were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with magnesium sulfate alone,and the observation group was treated with labetalol and magnesium sulfate.Both groups were compared in terms of clinical efficacy,clinical indicators[systolic blood pressure(SBP),diastolic blood pressure(DBP),24-h urinary protein excretion,heart rate(HR),fetal heart rate],incidence of adverse pregnancy outcomes,hemorheological indicators[fibrinogen(FIB),plasma viscosity(PV),low-shear viscosity(LBV),high-shear viscosity(HBV)],serum factors[C-reactive protein(CRP),homocysteine(Hcy),malondialdehyde(MDA),myeloperoxidase(MPO),endothelin-1(ET-1),nitric oxide(NO),superoxide dismutase(SOD),placental growth factor(PLGF)]levels.Results The total effective rate of the observation group was 94.00%,which was significantly higher than that of 74.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had SBP of(133.72±9.81)mm Hg(1 mm Hg=0.133 kPa),DBP of(85.16±6.30)mm Hg and 24-h urinary protein excretion of(1.81±0.57)g/24 h,which were significantly lower than those of(146.59±10.67)mm Hg,(94.73±7.08)mm Hg and(2.64±0.72)g/24 h in the control group,and the differences were statistically significant(P<0.05).After treatment,there was no statistically significant difference in HR and fetal heart rate between the two groups(P>0.05).The incidence of adverse maternal and perinatal pregnancy outcome in the observation group were 10.00%and 6.00%,which were lower than those of 26.00%and 22.00%in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of FIB,PV,LBV and HBV in the observation group were(2.32±0.41)g/L,(1.27±0.17)mPa·s,(7.52±0.83)mPa·s and(3.72±0.38)mPa·s

关 键 词：重度妊娠期高血压疾病 拉贝洛尔 硫酸镁 临床疗效 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]