Infrequent organ involvement in immunoglobulin G4-related prostate disease: A case report  

作　　者：Yi Yu Qian-Qian Wang Li Jian Deng-Can Yang 

机构地区：[1]Department of Critical Care Medicine,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510006,Guangdong Province,China [2]Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510000,Guangdong Province,China [3]Department of Critical Care Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong Province,China [4]Anesthesiology Department,The Central Hospital of Shaoyang,Shaoyang 422000,Hunan Province,China

出　　处：《World Journal of Clinical Cases》2023年第30期7485-7491,共7页世界临床病例杂志

基　　金：Supported by the Guangdong Provincial Bureau of Traditional Chinese Medicine,No.20222065;Science and Technology Planning Project of Guangdong Province of China,No.A2021100;National Natural Science Foundation of China,No.82104989。

摘　　要：BACKGROUND Immunoglobulin G4-related prostate disease(IgG4-RPD)characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings.Here we report a case of a patient who was successfully treated for IgG4-RPD,which manifested as frequent micturition,dysuric,and systemic lymphadenopathy.CASE SUMMARY The patient was a 33-year-old man who was referred to our hospital because of urinary tract symptoms that had persisted for 4 years.A physical examination revealed systemic lymphadenopathy and blood tests showed hyperglobulinemia with an IgG level of 18.90 g/L and an IgG4 level of 18.40 g/L.Computed tomography(CT)revealed bilateral lacrimal gland,right parotid gland and prostatic enlargement.Based on these findings,IgG4-RD was suspected,and further pathological examination and follow-up results showed expected results.Finally,the patient was diagnosed with IgG4-RPD based on clinical symptoms,pathological examination,therapeutic effects,and follow-up results.He received 50 mg oral prednisolone(the dose was gradually reduced and a low dose was used for long-term maintenance)in combination with cyclophosphamide 1.0 g via an intravenous drip for 6 mo.One year after the treatment was initiated,he was free of urinary or other complaints and his serum IgG4 level normalized.CONCLUSION In IgG4-RPD with severe urinary tract symptoms,radiological findings should be carefully examined.IgG4-RPD prognosis is good because the disease responds well to glucocorticoids.Furthermore,it is urgent for clinicians and pathologists to improve their understanding of IgG4-RPD.

关 键 词：Immunoglobulin G4-related prostate disease Infrequent organ involvement Systemic disease Pathological examination Glucocorticoids Case report 

分 类 号：R593.2[医药卫生—内科学]