神经调节蛋白-1在心肌缺血再灌注中的研究进展  

Research progress of Neuregulin-1 in myocardial ischemia-reperfusion

作　　者：许铭明 林冬铭 Xu Mingming;Lin Dongming(The Second Clinical College,Zhejiang Traditional Chinese Medicine University,Hangzhou 310053,China;Department of Cardiology,the Second Affiliated Hospital of Zhejiang Traditional Chinese Medicine University,Hangzhou 310015,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江中医药大学附属第二医院心内科,杭州310015

出　　处：《心脑血管病防治》2023年第4期30-33,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：浙江中医药大学校级研究生科研项目(2021YKJ07);浙江省基础公益研究计划项目(LQ20H270013);浙江省中医药科学研究基金项目(2020ZB122);浙江省中医药科学研究基金项目(2018ZB057)。

摘　　要：心肌缺血再灌注损伤过程中,心肌缺血梗死会导致心肌细胞不可逆的损伤,而缺血组织恢复血流灌注时,会引起再灌注区心肌细胞及局部血管网显著地病理生理变化,这些变化共同作用可促使进一步的组织损伤。目前临床药物和介入手术等治疗方法不能有效恢复心肌梗死后心脏的功能或失活的心肌。神经调节蛋白-1不仅在心脏组织的结构完整性中发挥重要作用,还可以通过抑制炎症反应与氧化应激、促进心脏血管形成、调节心肌重构等方式减轻心肌损伤,这使人们认识到其在治疗心肌缺血再灌注中的巨大潜力。本文将对神经调节蛋白-1在心肌缺血再灌注损伤中的研究进展进行综述和展望。In the process of myocardial ischemia-reperfusion injury,myocardial ischemia infarction can lead to irreversible damage of myocardial cells,and when blood perfusion is resumed in the ischemic tissue,significant pathophysiological changes of myocardial cells and local vascular network in the reperfusion area can be caused,and these changes can promote further tissue damage together.Current clinical drugs and interventional surgery can not effectively restore the function of the heart or inactivate the lost heart muscle after myocardial infarction.Neuregulin-1 not only plays an important role in the structural integrity of heart tissue,but also reduces myocardial injury by inhibiting inflammatory response and oxidative stress,promoting cardiac angiogenesis,regulating myocardial remodeling,etc.,which has also made people realize its great potential in the treatment of myocardial ischemia reperfusion.In this paper,the research progress of Neuregulin-1 in myocardial ischemia-reperfusion injury will be reviewed and prospeced.

关 键 词：神经调节蛋白-1 心肌缺血再灌注损伤 保护机制 再灌注治疗 

分 类 号：R542.2[医药卫生—心血管疾病]