固肾安胎丸联合烯丙雌醇片对复发性流产患者凝血功能及妊娠结局的影响  

Effects of Gushen Antai pill Combined with Allylestradiol tablet on Coagulation Function and Pregnancy outcome in Patients with Recurrent abortion

作　　者：王晓清[1] 张新华[2] WANG Xiaoqing;ZHANG Xinhua(Department of pharmacy,Zhengzhou maternal and child health hospital,Zhengzhou Henan 450007,China;Department of Obstetrics,Zhengzhou maternal and child health hospital,Zhengzhou Henan 450007,China)

机构地区：[1]郑州市妇幼保健院药学部,河南郑州450007 [2]郑州市妇幼保健院秦岭路院区产科五区,河南郑州450007

出　　处：《临床研究》2023年第11期130-133,共4页Clinical Research

摘　　要：目的 分析固肾安胎丸与烯丙雌醇片联合治疗对复发性流产(RSA)患者凝血功能及妊娠结局的影响。方法 以随机数字表法将郑州市妇幼保健院2022年1月至2022年12月接收的100例RSA患者分为参照组(50例)、联合组(50例)。参照组予以烯丙雌醇治疗,联合组予以固肾安胎丸联合烯丙雌醇治疗。比较两组疗效、治疗前后中医证候积分、性激素水平[雌二醇(E_(2))、孕酮(P)、人绒毛膜促性腺激素(HCG)]、凝血功能[纤维蛋白原(FIB)、组织型纤溶酶原活化因子(t-PA)、部分凝血酶原时间(APTT)、纤溶酶原激活物抑制剂-1(PAI-1)]、血管生成相关因子[促血管生成素-2(Ang-2)、胎盘生长因子(PLGF)]、妊娠结局、不良反应。结果 联合组治疗有效率(96.00%)高于参照组(80.00%);治疗后联合组E_(2)、P、HCG均高于参照组,中医证候积分低于参照组,差异有统计学意义(P<0.05)。治疗后两组APTT比较,差异无统计学意义(P> 0.05),联合组t-PA高于参照组,FIB、PAI-1低于参照组,差异有统计学意义(P<0.05)。治疗后联合组Ang-2、PLGF水平均高于参照组;联合组活产率(96.00%)高于参照组(80.00%),差异有统计学意义(P<0.05)。两组不良反应发生率均为8.00%,差异无统计学意义(P> 0.05)。结论 固肾安胎丸与烯丙雌醇片联合治疗RSA疗效确切,可调节性激素及血管生成因子水平,改善凝血功能,促进症状恢复,提高妊娠成功率,且不增加不良反应。Objective To analyze the effect of Guishen An Tai Pills combined with Ethinylestradiol tablets on the coagulation function and pregnancy outcome of patients with Recurrent Spontaneous Abortion(RSA).Methods 100 RSA patients admitted to Zhengzhou Maternal and Child Health Hospital from January 2022 to December 2022 were divided into reference group(50 cases)and combination group(50 cases)by random number table method.The reference group was treated with Ethinylestradiol,and the combination group was treated with Guishen An Tai Pills combined with Ethinylestradiol.The efficacy,TCM syndrome score before and after treatment,sex hormone levels[Estradiol(E_(2)),Progesterone(P),Human Chorionic Gonadotropin(HCG)],coagulation function[Fibrinogen(FIB),Tissue-type Plasminogen Activator(t-PA),Activated Partial Thromboplastin Time(APTT),Plasminogen Activator Inhibitor-1(PAI-1)],angiogenesis-related factors[Angiopoietin-2(Ang-2),Placental Growth Factor(PLGF)],pregnancy outcome,and adverse reactions were compared between the two groups.Results The effective rate of treatment in the combination group(96.00%)was higher than that in the reference group(80.00%);after treatment,E_(2),P,HCG in the combination group were higher than those in the reference group,and TCM syndrome score was lower than that in the reference group,the difference was statistically significant(P<0.05).After treatment,there was no significant difference in APTT between the two groups(P>0.05),t-PA in the combination group was higher than that in the reference group,FIB,PAI-1 were lower than those in the reference group,the difference was statistically significant(P<0.05).After treatment,Ang-2,PLGF levels in the combination group were higher than those in the reference group;the live birth rate in the combination group(96.00%)was higher than that in the reference group(80.00%),the difference was statistically significant(P<0.05).The incidence of adverse reactions in both groups was 8.00%,and there was no significant difference(P>0.05).Conclusion The combination

关 键 词：固肾安胎丸 烯丙雌醇片 复发性流产 妊娠结局 

分 类 号：R203.1[医药卫生—中医学]