子痫前期并发胎儿生长受限临床特征及母婴结局分析  

Clinical Characteristics and Maternal and Infant Outcomes of Preeclampsia Complicated with Fetal Growth Restriction

作　　者：戴小燕 朱琳飞 于威威 DAI Xiaoyan;ZHU Linfei;YU Weiwei(Women and Children's Hospital Affiliated to Xiamen University,Xiamen Maternal and Child Health Care Hospital,Xiamen 361003,China)

机构地区：[1]厦门大学附属妇女儿童医院,厦门市妇幼保健院,福建厦门361003

出　　处：《中国医药指南》2023年第30期1-4,共4页Guide of China Medicine

基　　金：厦门市医疗卫生指导性项目,编号3502Z20209201。

摘　　要：目的 探讨子痫前期(PE)合并胎儿生长受限(FGR)的临床特征和母婴结局。方法 对2020年1月至2022年12月在厦门市妇幼保健院产科就诊并分娩的740例单胎子痫前期患者的病例资料进行回顾性分析。根据是否并发FGR分为FGR组85例(观察组)和未并发FGR组655例(对照组)。比较两组的一般情况、临床数据、母体并发症合并症及新生儿资料。结果 研究期间我院子痫前期患者并发FGR的发生率为11.49%,其中早发型及晚发型子痫前期并发FGR的发生率分别为65.96%和7.79%(P<0.05);观察组的分娩孕周明显小于对照组(P<0.05);观察组的死胎率、剖宫产率、住院天数均明显高于对照组,HELLP综合征、胎盘早剥、羊水过少、胎儿宫内窘迫及胎儿脐血流异常的发生率明显高于对照组(P<0.05);观察组≥28周不同孕周阶段的新生儿平均体质量、平均身长及平均头围均低于对照组,观察组新生儿肺炎、视网膜病、围生期脑损伤、湿肺、新生儿贫血的发生率都明显高于对照组(P<0.05)。结论 子痫前期患者一旦并发FGR时,出现母婴不良结局的风险增加,临床工作中需早期识别,加强监护,降低不良母婴结局。Objective To investigate the clinical characteristics and maternal and infant outcomes of preeclampsia(PE)complicated with fetal growth restriction(FGR).Methods A retrospective analysis was made on the data of 740 cases of singleton preeclampsia who were admitted to the Department of Obstetrics,Xiamen Maternal and Child Health Hospital from January 2020 to December 2022.According to whether there were complications of FGR,85 cases in the FGR group(observation group)and 655 cases in the control group were divided into two groups.The general situation,clinical data,maternal complications and neonatal data of the two groups were compare.Results The incidence of FGR in PE patients in our hospital during this period was 11.49%,among which the incidence of FGR in early-onset and late-onset PE patients was 65.96%and 7.79%,respectively(P<0.05).The gestational age of the observation group was significantly lower than that of the control group(P<0.05).The stillbirth rate,cesarean section rate and hospital days in observation group were significantly higher than those in control group,and the incidence of HELLP syndrome,placental abruption,oligohydramnios,fetal distress and abnormal umbilical cord blood flow in observation group were significantly higher than those in control group(P<0.05).The average body weight,average body length and average head circumference of neonates in observation group were lower than those in control group at different gestational stages≥28 weeks,and the incidence of neonatal pneumonia,retinopathy,perinatal brain injury,wet lung and neonatal anemia in observation group were significantly higher than those in control group,with statistical significance(P<0.05).Conclusions Once patients with preeclampsia are complicated with FGR,there is an increased risk of adverse maternal and infant outcomes.In clinical work,early identification and intensive monitoring are needed to reduce adverse maternal and infant outcomes.

关 键 词：子痫前期 胎儿宫内生长受限 母婴结局 

分 类 号：R714.244[医药卫生—妇产科学]