多囊卵巢综合征抗缪勒管激素和促甲状腺激素与血脂代谢的相关性  

Correlation between anti müller hormone,thyroid-stimulating Hormone and Lipid Metabolism in polycystic Ovary Syndrome

作　　者：王建斌[1] 袁慧[2] Wang Jianbin;Yuan Hui(Department of Laboratory Medicine,Yanqing District Hospital,Peking University Third Hospital,Yanqing District Hospital,Beijing,102100,China;Department of Laboratory Medicine,Capital University of Medical Sciences,Beijing,100029,China)

机构地区：[1]北京市延庆区医院,北京大学第三医院延庆医院检验科,北京102100 [2]首都医科大学附属北京安贞医学检验科,北京100029

出　　处：《中外女性健康研究》2023年第19期4-6,共3页Women＇s Health Research

基　　金：北京市延庆区金桥工程种子基金(编号:21013)。

摘　　要：目的:分析多囊卵巢综合征中抗缪勒管激素和促甲状腺激素与血脂代谢的相关性。方法:选取2020年6月至2022年6月来延庆区医院妇科门诊就诊患者,将其中符合多囊卵巢综合征症状患者238例作为观察组,同期在体检中心选取符合条件的健康育龄妇女238例作为对照组。对比两组所有样本中抗缪勒管激素(AMH)、促甲状腺激素(TSH)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),小而密低密度脂蛋白(sdLDL-c)的水平,并采用Person分析抗缪勒管激素与其他各指标的相关性。结果:观察组抗缪勒管激素、促甲状腺激素、三酰甘油、小而密低密度脂蛋白水平高于对照组,其中多囊卵巢综合征患者AMH、TG水平明显高于对照组,差异具备统计学意义(P<0.05),而两组小而密低密度脂蛋白对比结果无统计学意义(P>0.05)。观察组抗缪勒管激素水平与高密度脂蛋白胆固醇水平呈正相关性(r=0.563,P<0.001),与TSH、LDL-C、sdLDL-C、TG无相关性(P>0.05);促甲状腺激素与LDL-C、sdLDL-C呈正相关(r=0.489、0.401,均P<0.01)。正常对照组仅AMH与HDL-C呈正相关(r=0.589,P<0.01),与TSH、LDL-C、sdLDL-C、TG无相关性(P>0.05);TSH与HDL-C、TG、LDL-C、sdLDL-C也无相关性(P>0.05)。结论:多囊卵巢综合征患者的抗缪勒管激素浓度显著增高,且与高密度脂蛋白水平密切相关,促甲状腺激素与脂代谢指标有相关性,通过分析血清AMH、TSH及脂蛋白浓度以及三者之间的相关性对多囊卵巢综合症的临床诊断及预后指导有一定的作用。Objective:To investigate the relationship between anti müller-hormone,thyroid-stimulating hormone and lipid metabolism in polycystic ovary syndrome(pcos).Methods:A total of 238 patients with pcos diagnosed in Yanqing District Hospital from June 2020 to June 2022 were selected as the observation group,and 238 healthy women of childbearing age who met the conditions in the physical examination center were selected as the control group.Levels of anti Müller hormone,thyroid-stimulating Hormone,triglyceride,high-density lipoprotein cholesterol(HDL-C),Low-density Lipoprotein(LDL-C),and small dense low-density lipoprotein-cholesterol(sdLDL-C)were compared between the two groups,and Person was used to analyze the correlation between anti-Mullerian hormone and other indicators.Results:The levels of anti Müller hormone,thyroid-stimulating Hormone,triglyceride and Low-density Lipoprotein in the observation group were significantly higher than those in the control group.The levels of Amh and TG in PCOS patients were significantly higher than those in the Control Group(P<0.05).There was no significant difference in the level of small dense low-density lipoprotein-cholesterol between the two groups(P>0.05).There was a positive correlation between Müller hormone levels and high-density lipoprotein cholesterol levels in the observation group(r=0.563,P<0.001).There was no correlation between TSH,LDL-C,sdLDL-C and TG(P>0.05)and positive correlation between thyroid-stimulating Hormone and LDL-C,sdLDL-C(r=0.489,0.401,P<0.01).In normal control group,only AMH was positively correlated with HDL-C(r=0.589,P<0.01),but not with TSH,LDL-C,sdLDL-C and TG(P>0.05),and TSH was not correlated with HDL-C,TG,LDL-C and sdLDL-C(P>0.05).Conclusion:The concentration of anti muller hormone was significantly increased in patients with PCOS,which was closely related to the level of high-density lipoprotein,and thyroid-stimulating hormone was correlated with lipid metabolism,the analysis of Serum AMH,TSH and lipoprotein concentrations and their corre

关 键 词：多囊卵巢综合征 抗缪勒管激素 促甲状腺激素 血脂 

分 类 号：R446.6[医药卫生—诊断学]