输尿管结石梗阻所致的急性肾功能损伤患者血清KIM-1、PCT、cys C水平变化及意义  

Serum Levels and Significance of KIM-1,PCT and cys C in Patients with Acute Kidney Injury Caused by Ureteral Stone Obstruction

作　　者：李卿英 任梦楠 LI Qingying;REN Mengnan(Department of Urology,The Third Hospital of Xi'an,Xi'an Shaanxi 710021)

机构地区：[1]西安市第三医院泌尿外科,陕西西安710021 [2]延安大学咸阳医院检验科,陕西咸阳712000

出　　处：《医学临床研究》2023年第9期1311-1314,共4页Journal of Clinical Research

摘　　要：【目的】探讨输尿管结石梗阻所致的急性肾功能损伤(AKI)患者的血清肾损伤分子-1(KIM-1)、降钙素原(PCT)、胱抑素C(cys C)水平变化及意义。【方法】两院收治的90例输尿管结石梗阻患者,根据患者在院内是否发生AKI分为AKI组(15例)和非AKI组(75例)。比较两组患者相关临床资料及KIM-1、PCT、cys C水平的差异,使用单因素和多因素Logistic回归分析影响输尿管结石梗阻患者发生早期AKI的独立危险因素,绘制受试者工作特征(ROC)曲线评价相关指标对输尿管结石梗阻患者发生早期AKI的预测价值。【结果】AKI组KIM-1、PCT、cys C水平均高于非AKI组(P<0.05),两组其他临床资料比较,差异均无统计学意义(P>0.05)。多因素Logistic回归分析显示,KIM-1、PCT、cys C是影响输尿管结石梗阻患者发生早期AKI的独立危险因素(P<0.05)。ROC曲线显示,KIM-1、PCT、cys C对输尿管结石梗阻患者发生早期AKI均有一定预测效能,曲线下面积(AUC)分别为0.806、0.829和0.754;三项指标联合预测输尿管结石梗阻患者发生早期AKI的AUC为0.927。【结论】KIM-1、PCT、cys C在输尿管结石梗阻所致AKI患者血清中的表达明显升高,是影响早期AKI发生的独立危险因素,三项指标联合检测可作为早期诊断AKI发生的筛选指标。【Objective】To investigate the changes and significance of Kidney Injury Molecule-1(KIM-1),Procalcitonin(PCT),and Cystatin C(cys C)levels in the serum of patients with Acute Kidney Injury(AKI)caused by ureteral stone obstruction.【Methods】Ninety patients with ureteral stone obstruction admitted to our hospital were included in the study.Patients were divided into the AKI group(15 cases)and the non-AKI group(75 cases)based on whether AKI occurred during hospitalization.The differences in clinical data and levels of KIM-1,PCT,and cys C were compared between the two groups.Univariate and multivariate logistic regression analyses were used to evaluate the independent risk factors influencing the early occurrence of AKI in patients with ureteral stone obstruction.Receiver operating characteristic(ROC)curves were drawn to evaluate the predictive value of related indicators for the early occurrence of AKI in these patients.【Results】The levels of KIM-1,PCT,and cys C were higher in the AKI group than in the non-AKI group(P<0.05).The differences of clinical data between the two groups were not statistically significant(P>0.05).Multivariate logistic regression analysis showed that KIM-1,PCT,and cys C were independent risk factors affecting the early occurrence of AKI in patients with ureteral stone obstruction(P<0.05).ROC curves showed that KIM-1,PCT,and cys C all had certain predictive efficacy for the early occurrence of AKI in patients with ureteral stone obstruction,with areas under the curve(AUC)of 0.806,0.829,and 0.754,respectively.The combined prediction of the three indicators for the early occurrence of AKI in patients with ureteral stone obstruction had an AUC of 0.927.【Conclusion】The expressions of KIM-1,PCT,and cys C in the serum of patients with AKI caused by ureteral stone obstruction are significantly elevated.They are independent risk factors influencing the early occurrence of AKI,and the combined detection of these three indicators can be used as a screening index for the early occurrence of

关 键 词：输尿管结石/并发症 急性肾损伤/并发症 降钙素原/血液 抑素类/血液 

分 类 号：R693.4[医药卫生—泌尿科学]