不同剂量米非司酮用于子宫肌瘤合并贫血患者对性激素水平的影响  

Effects of Different Doses of Mifepristone on Sex Hormone Levels in Patients with Uterine Fibroid and Anemia

作　　者：董莉君 王薇 DONG Lijun;WANG Wei(Department of Gynecology,Pucheng County Hospital,Weinan Shaanxi 715500)

机构地区：[1]蒲城县医院妇科,陕西渭南715500 [2]蓝田县人民医院妇产科,陕西西安710500

出　　处：《医学临床研究》2023年第9期1371-1374,共4页Journal of Clinical Research

摘　　要：【目的】探讨不同剂量米非司酮用于子宫肌瘤合并贫血患者对性激素水平的影响。【方法】选取蒲城县医院2019年3月至2021年3月收治的90例子宫肌瘤合并贫血患者,按照随机数字表法分为观察组和对照组,每组45例。对照组术前采用大剂量米非司酮(20 mg/次)治疗,观察组术前采用小剂量米非司酮(10 mg/次)治疗。比较两组患者手术时间、术中出血量、住院天数、术后24 h血红蛋白含量、用药后不良反应发生情况及治疗前后性激素[促黄体生成素(LH)、孕酮(P)、促卵泡激素(FSH)、雌二醇(E_(2))]水平、子宫肌瘤直径、子宫体积、生活质量量表(QOL)评分。【结果】两组患者手术时间、术中出血量、住院天数、术后24 h血红蛋白量比较,差异无统计学意义(P>0.05);两组患者治疗后LH、P、FSH、E_(2)水平均低于同组治疗前,差异有统计学意义(P<0.05);两组患者治疗后肌瘤直径、子宫体积均小于同组治疗前,QOL评分均高于同组治疗前,差异有统计学意义(P<0.05);观察组患者用药后不良反应发生率(15.56%)明显低于对照组(35.56%),差异有统计学意义(P<0.05)。【结论】子宫肌瘤合并贫血患者术前应用小剂量米非司酮可有效降低性激素水平,减小肌瘤体积,且安全性高。【Objective】To investigate the effect of different doses of mifepristone on sex hormone levels in patients with Uterine fibroid and anemia.【Methods】From March 2019 to March 2021,90 patients with Uterine fibroid and anemia in the Pucheng County Hospital were selected and divided into observation group and control group according to random number table,with 45 cases in each group.The control group received high-dose mifepristone(20 mg/dose)treatment before surgery,while the observation group received low-dose mifepristone(10 mg/dose)treatment before surgery.The operation time,intraoperative blood loss,hospital stay,hemoglobin content 24 hours after operation,adverse reactions after medication,levels of sex hormones[luteinizing hormone(LH),progesterone(P),Follicle-stimulating hormone(FSH),estradiol(E_(2))],diameter of Uterine fibroid,uterine volume,and quality of life scale(QOL)scores were compared between the two groups.【Results】There was no statistically significant difference(P>0.05)between the two groups in terms of surgical time,intraoperative bleeding volume,length of hospital stay,and postoperative 24 hour hemoglobin levels;The levels of LH,P,FSH,and E_(2) in the two groups of patients after treatment were lower than those in the same group before treatment,and the difference was statistically significant(P<0.05);After treatment,the diameter of fibroids and uterine volume of the two groups of patients were smaller than that before treatment,and the QOL scores was higher than that before treatment,with a statistically significant difference(P<0.05);The incidence of adverse reactions after medication in the observation group(15.56%)was significantly lower than that in the control group(35.56%),with a statistically significant difference(P<0.05).【Conclusion】Preoperative use of low-dose mifepristone in patients with Uterine fibroid and anemia can effectively reduce the level of sex hormones,reduce the volume of leiomyoma,and has high safety.

关 键 词：平滑肌瘤/并发症 贫血/并发症 米非司酮/投药和剂量 性腺甾类激素 

分 类 号：R711.74[医药卫生—妇产科学]