宽胸气雾剂对急性心肌梗死患者经皮冠状动脉介入术后冠脉微循环的影响  

Effect of Kuanxiong Aerosol for Coronary Microcirculation in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention

作　　者：梁津焕 蔡银河[1] 黎燚华 褚庆民[2] 赵新军[2] 李荣[2] LIANG Jin-huan;CAI Yin-he;LI Yi-hua;CHU Qing-min;ZHAO Xin-jun;LI Rong(First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405;Department of Cardiology,First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510120)

机构地区：[1]广州中医药大学第一临床医学院,广州510405 [2]广州中医药大学第一附属医院心血管科,广州510120

出　　处：《中国中西医结合杂志》2023年第9期1052-1055,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察宽胸气雾剂舌下给药对急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)治疗术后冠脉微循环的影响。方法将63例接受PCI治疗后的AMI患者随机分成试验组(32例)和对照组(31例)。对照组术后给予常规西医治疗;试验组患者在对照组基础上,在行PCI术前给予宽胸气雾剂舌下给药1次,共3喷,术后继续予宽胸气雾剂舌下给药3喷/次,每天3次,疗程7天。评价治疗前后TIMI血流分级、校正TIMI帧计数(CTFC)、肌酸激酶同工酶(CK-MB)达峰时间及峰值,记录住院期间主要不良心血管事件。结果63例患者均完成研究并纳入统计分析。与对照组比较,试验组治疗后CTFC降低(P<0.05)。两组TIMI血流分级、CK-MB峰值、CK-MB达峰时间、心血管事件发生率比较,差异均无统计学意义(P>0.05)。结论AMI患者PCI术前及术后使用宽胸气雾剂可改善冠脉微循环。Objective To observe the effect of Kuanxiong Aerosol for coronary microcirculation in acute myocardial infarction(AMI)patients who received percutaneous coronary intervention(PCI)therapy.Methods Totally 63 AMI patients who received PCI were randomly assigned to the experimental group(32 cases)and the control group(31 cases).The control group received conventional treatment after PCI.The experimental group was given sublingually Kuanxiong Aerosol 3 sprays for 1 time before PCI,and 3 spray sper time,3 time sper day for 7 days on the base of conventional treatment.The thrombolysis in myoeardial infarction(TIMI)blood flow grading,TIMI frame count corrected(CTFC),peak time and peak value of creatine kinase isoenzyme(CK-MB)after intervention were evaluated before and after treatment.The adverse cardiovascular events during hospitalization were recorded at the same time.Results All 63 patients completed the study and were included in statistical analysis.Compared with the control group,CTFC decreased in experimental group after treatment(P<0.05).There was no significant difference in TIMI blood flow grading,CK-MB peak value,CK-MB peak time,incidence of cardiovascular events(P>0.05).Conclusion The treatment of Kuanxiong Aerosol before and after PCI in AMI patients could improve coronary microcirculation.

关 键 词：宽胸气雾剂 经皮冠状动脉介入 冠脉微循环 

分 类 号：R542.22[医药卫生—心血管疾病]