职业性锑暴露与肺癌相关性及其致癌机制研究进展  

Research progress on the association of occupational antimony exposure with lung cancer and its carcinogenic mechanism

作　　者：高澜 金岚菲 陈光弟[1] Gao Lan;Jin Lanfei;Chen Guangdi(School of Public Health,School of Medicine,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学医学院公共卫生学院,杭州310058

出　　处：《中华劳动卫生职业病杂志》2023年第9期710-714,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金(82173487)。

摘　　要：流行病学研究提示,职业性锑暴露与肺癌发生风险增加相关。三价锑致实验动物肺癌的证据充分,在人类原代细胞和实验系统中已具备有力的机制证据。国际癌症研究机构(IARC)将三价锑列为很可能人类致癌物(2A类),美国国家毒理学计划(NTP)认为三氧化二锑(Sb_(2)O_(3))是一种人类致癌物。锑及其化合物可引起染色体断裂和/或DNA损伤,氧化应激致DNA氧化损伤、抑制DNA损伤修复可能是锑致癌作用的主要机制。本文综述了职业性锑暴露与肺癌的流行病学调查研究以及锑暴露致癌作用的实验研究进展,总结以往研究中存在的问题并展望未来研究方向。Previous epidemiological studies suggested that occupational antimony exposure was associated with an increased risk of lung cancer.The evidence is sufficient for carcinogenicity of trivalent antimony in experimental animals,and strong mechanistic evidence has been observed in human primary cells and experinental systems.Thus,trivalent antimony has been classified as possibly carcinogenic to humans(Group 2A)by International Agency for Research on Cancer(IARC),and the United States National Toxicology Program(NTP)classified Sb_(2)O_(3) as a human carcinogen.Antimony and its compounds could induce chromosome breakage and/or DNA damage.Oxidative damage of DNA under oxidative stress and inhibition of DNA damage repair may be the main mechanism of antimony carcinogenesis.This review summarizes the epidemiological investigation of occupational antimony exposure and lung cancer,as well as the experimental research progression on the carcinogenic effects of antimony exposure,and discusses the limitations of previous studies and future research directions.

关 键 词：锑 职业暴露 肺癌 遗传毒性 氧化应激 

分 类 号：R135[医药卫生—劳动卫生] R734.2[医药卫生—公共卫生与预防医学]