长链非编码RNA在矽肺纤维化发病机制中的作用研究  

The role of long non-coding RNA in the pathogenesis of pulmonary fibrosis of silicosis

作　　者：姚佳慧 楼建林 Yao Jiahui;Lou Jianlin(Hanzhou Medical College,School of Public Health(Zhejiang Acaderay of Medical Science),Hangzhou 310013,China)

机构地区：[1]杭州医学院公共卫生学院(浙江省医学科学院),杭州310013

出　　处：《中华劳动卫生职业病杂志》2023年第9期715-720,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家重点研发计划国际合作重点专项(2019YFE0116100);国家卫生健康委员会科研基金(WKJ-ZJ-2022)。

摘　　要：矽肺是一种由于长期吸入大量游离晶体二氧化硅所引起的进行性肺纤维化疾病,严重威胁相关劳动作业人员的健康,造成严重的疾病负担。矽肺的发病机制较为复杂且不明确,长链非编码RNA(lncRNA)在矽肺发病机制中起到重要作用。本文对矽肺发病和疾病进展过程中lncRNA的作用机制进行综述,以期提高对该疾病的认识,为矽肺的防治提供思路。Silicosis is a progressive pulmonary fibrosis disease caused by long-term inhalation of a large amount of free crystalline silica,which seriously threatens the health of relevant workers and causes a huge amount of disease burden.The pathogenesis of silicosis is complex and unclear,it has been reported that long non coding RNA(lncRNA)plays an important role in the pathogenesis of silicosis.In order to improve the understanding of the disease and provide directions for the prevention and treatment of silicosis,this article reviewed the mechanism of lncRNA in the pathogenesis and disease progression of silicosis.

关 键 词：矽肺 长链非编码核糖核酸 肺纤维化 微小核糖核酸 信号通路 信使核糖核酸转录 

分 类 号：R135.2[医药卫生—劳动卫生]