钾离子通道在帕金森病中的研究进展  

Progress of potassium channels in Parkinson's disease

作　　者：付强 刘紫欣 贾钧儒 高志伟 付静璇 安海龙 FU Qiang;LIU Zixin;JIA Junru;GAO Zhiwei;FU Jingxuan;AN Hailong(Key Laboratory of Molecular Biophysics,Hebei Province,Institute of Biophysics,School of Sciences,Hebei University of Technology,Tianjin 300401,China;School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130,China)

机构地区：[1]河北工业大学理学院生物物理研究所河北省分子生物物理重点实验室,天津300401 [2]河北工业大学化工学院,天津300130

出　　处：《河北工业大学学报》2023年第5期30-38,共9页Journal of Hebei University of Technology

基　　金：河北省自然科学基金(C20202010)。

摘　　要：帕金森病(PD)是第二大神经退行性疾病,其致病机制与黑质(SN)中的多巴胺神经元严重丢失、α-突触核蛋白的大量积累有关。钾(K^(+))通道在中枢神经系统中广泛分布,在调节细胞兴奋性、突触传递和神经递质的释放中起关键作用。大量文献表明PD发生与K^(+)通道功能异常密切相关,PD也被认为是离子通道疾病。近年来的研究显示,干预K^(+)通道可以显著影响PD患者的运动和非运动障碍。本文对K^(+)通道在PD中的作用进行了综述,总结并讨论了干预K^(+)通道在PD治疗中的影响,为PD的预防和治疗提供新思路。Parkinson's disease is the second commonest neurodegenerative disease.Its pathogenic mechanism is related to the severe loss of dopaminergic neurons in the substantia nigra and the large accumulation ofα-synuclein.Potassium channels are widely distributed in the central nervous system and play a key role in regulating cell excitability,synaptic transmission and neurotransmitter release.A large number of literature show that the occurrence of Parkinson's disease is closely related to the abnormal function of potassium channels.Also,Parkinson's disease is also considered to be an ion channel disease.Recent studies show that regulation of potassium channels can significantly affect the movement and non-motor disorders of Parkinson's disease.In this review,the authors summarized the roles of potassium channels in Parkinson's disease and discussed the impact of intervention of potassium channels in the treatment of Parkinson's disease to provide new ideas for the prevention and treatment of Parkinson's disease.

关 键 词：钾通道 帕金森病 多巴胺神经元 电压门控钾离子通道 内向整流钾离子通道 

分 类 号：Q6[生物学—生物物理学]