分子修饰纳米载体提高口服药物生物利用度的研究进展  

Research progress on molecularly modified nanocarriers with the improvement oral bioavailability of drugs

作　　者：霍代夏 吕晓洁 安秋旭 梁晓凤[2] 顾艳丽 HUO Daixia;LÜXiaojie;AN Qiuxu;LIANG Xiaofeng;GU Yanli(School of Pharmacy,Inner Mongolia Medical University,Hohhot,Inner Mongolia,010000 P.R.China;Department of Cardiorascular Surgery,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia,010000 P.R.China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010000 [2]内蒙古医科大学附属医院心脏大血管外科,内蒙古呼和浩特010000

出　　处：《华西药学杂志》2023年第5期575-580,共6页West China Journal of Pharmaceutical Sciences

摘　　要：由于药物自身性质与胃肠道吸收屏障,口服给药的生物利用度受到限制。纳米载体对药物口服生物利用度提高的效果有限,修饰可显著提高纳米载体穿越胃肠道屏障的能力。现综述不同分子修饰纳米载体穿越吸收屏障的机制及改善药物口服生物利用度的研究,为设计口服纳米载体提供了参考。Due to the nature of the drug itself and the absorption barrier of the gastrointestinal tract,the bioavailability of oral administration is limited.The effectiveness of nanocarriers in improving the oral bioavailability of drugs is limited.Modification can significantly improve the ability of nanocarriers to cross the gastrointestinal barrier.This paper reviews the mechanism of different molecularly modified nanocarriers crossing the absorption barrier and the research on improving the oral bioavailability of drugs,which provides a reference for the design of oral nanocarriers.

关 键 词：口服 纳米载体 分子修饰 口服生物利用度 黏液屏障 胃肠道环境 

分 类 号：R94[医药卫生—药剂学]