骨髓间充质干细胞衰老与骨质疏松症的研究进展  

Progress in senescence of bone marrow mesenchymal stem cells and osteoporosis

作　　者：李小云 林青 王昊宇 欧阳欣辰 杨丽[1,4] 朱晓峰 张荣华 LI Xiaoyun;LIN Qing;WANG Haoyu;OUYANG Xinchen;YANG Li;ZHU Xiaofeng;ZHANG Ronghua(College of Pharmacy,Jinan University,Guangzhou 510632,China;College of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China;The First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization,Guangzhou 510632,China)

机构地区：[1]暨南大学药学院,广东广州510632 [2]暨南大学中医学院,广东广州510632 [3]暨南大学第一附属医院,广东广州510630 [4]广东省中医药信息化重点实验室,广东广州510632

出　　处：《中国病理生理杂志》2023年第10期1898-1903,共6页Chinese Journal of Pathophysiology

基　　金：国家重点研发计划项目(No.2018YFC2002500);国家自然科学基金面上项目(No.81973717;No.82074287;No.82274232;No.82274376);广东省科技计划项目-广东省中医药信息化重点实验室(No.2021B1212040007);中央高校基本科研业务专项资金项目(No.21622329)。

摘　　要：骨质疏松症(osteoporosis, OP)是临床上常见的老年病,以骨量减少、骨微结构退化为特征,导致骨脆性及骨折风险增加。2018年国家卫生健康委发布的最新流行病学调查报告显示,我国40~49岁人群中OP的患病率为3.2%,50岁以上人群为19.2%,65岁以上则高达32.0%^([1]),随着年龄的增长OP患病率逐级递增,提示衰老与OP的发生密切相关。Osteoporosis is a common clinical disease of bone metabolism associated with aging,and its preva‐lence increases with age.The primary cause of this disease is the imbalance of bone metabolism due to insufficient bone formation to offset the excessive bone resorption.Osteogenic differentiation of bone marrow mesenchymal stem cells is a key process in maintaining bone formation,and the decline in osteogenic differentiation ability of bone marrow mesenchy‐mal stem cells caused by senescence plays a vital role in the pathological mechanism of osteoporosis.In this light,the present article summarizes the senescence mechanism of bone marrow mesenchymal stem cells and its relationship with os‐teoporosis,and intends to provide a new perspective for the prevention and treatment of osteoporosis.

关 键 词：骨髓间充质干细胞 衰老 骨质疏松症 

分 类 号：R681[医药卫生—骨科学] R363[医药卫生—外科学] R329.2[医药卫生—临床医学]