Protective Effect and Mechanism of n-butanol Extract from Diploclisia glaucescens(B1.)Diels on Rats with Adjuvant Arthritis  

作　　者：Chuhui ZHOU Zhouyan HUANG Fengxian ZHAO Yong CHEN Xianxian LIU Xiaolian LIANG Wenli LI 

机构地区：[1]Guangxi University of Chinese Medicine,Nanning 530200,China

出　　处：《Medicinal Plant》2023年第5期45-48,共4页药用植物：英文版

基　　金：Supported by Guangxi First-class Discipline Construction Project(2018xk060;2019xk105);Open Project of Guangxi Key Laboratory of Zhuang and Yao Medicine(GXZYKF2019-2,GXZYKF2022-11);Research Project of Guangxi Key Laboratory of Pharmacodynamic Research of Traditional Chinese Medicine(19-050-39-A6);Program of Key Laboratory for Purification and Quality Analysis of TCM Extraction in Guangxi Universities(Gui Jiao Ke Yan[2014]No.6).

摘　　要：[Objectives]To study the protective effect and mechanism of n-butanol extract of Diploclisia glaucescens(B1.)Diels on rats with adjuvant arthritis.[Methods]A rat adjuvant arthritis(AA)model with similarities to a clinical RA(rheumatoid arthritis)patient was used,and the model was made by injection of Complete Freund s adjuvant(CFA).Body mass and joint swelling degree were used as indicators,and the organ index was calculated and the synovial tissue of rats was examined under microscope to evaluate the protective effect of n-butanol extract on arthritis.The effects of n-butanol extract on TNF-α,IL-1βand PGE_(2)contents in rat serum were detected by ELISA kit.[Results]Arthritic rats experienced significant weight loss;the n-butanol extract reduced the joint swelling in rats.It exerted an effect on rat organs and reduced the contents of TNF-α,IL-1βand PGE_(2) in rat serum,and also reduced synovial inflammation in rats.[Conclusions]The n-butanol extract of D.glaucescens can protect rats with adjuvant arthritis by reducing the content of inflammatory factors.

关 键 词：Diploclisia glaucescens(B1.)Diels n-butanol extract Rats with adjuvant arthritis 

分 类 号：R285.5[医药卫生—中药学]