Protective Effect of Ethanol Extract from Sweet Potato Leaves on CCL_(4)-Induced Liver Injury in Mice  

作　　者：Chenchen HUANG Haihua LU Ting ZHAO Xiangting QIN Ting WEI Yingjun HE Suoyi HUANG Zhongshi HUANG 

机构地区：[1]College of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000,China [2]College of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China [3]Key Laboratory of Guangxi s College for the Study of Characteristic Medicine in Youjiang River Basin,Youjiang Medical University for Nationalities,Baise 533000,China [4]Department of Science and Technology,Youjiang Medical University for Nationalities,Baise 533000,China

出　　处：《Medicinal Plant》2023年第5期49-51,共3页药用植物：英文版

基　　金：Supported by National College Students Innovation and Entrepreneurship Training Program(202110599016);Guangxi Key R&D Project(GuiKeAB 18221095).

摘　　要：[Objectives]To investigate the protective effect of ethanol extract from sweet potato leaves on liver injury induced by CCl_(4)in mice.[Methods]25 ICR mice were randomly divided into blank group,model group,high-dose extract group(200 mg/kg),low-dose extract group(100 mg/kg)and positive control group(2 mg/kg colchicine),with 5 mice in each group.All groups except the blank group were given intraperitoneal injection of 20%CCl 4 olive oil solution(2 mL/kg),and the blank group was given the same dose of olive oil solution three times a week.After 4 weeks,each administration group was given the corresponding dose of drugs(10 mL/kg),and the blank group and model group were given the corresponding amount of normal saline for 2 weeks.After the last intragastric administration,fasting was required,but water was allowed,blood was taken from eyeballs,and upper serum was taken by static centrifugation.Serum AST,ALT,CRP,IL-6 and SOD levels were detected by the kit.[Results]Compared with the blank group,the serum AST and ALT levels in the model group were significantly increased;compared with the model group,the ethanol extract of sweet potato leaves could decrease the levels of ALT,AST,CRP,IL-6 and increase the level of SOD in serum.[Conclusions]The ethanol extract of sweet potato leaves had protective effect on the mice with liver injury induced by CCl_(4),and its mechanism may be to protect the liver by lowering enzymes,inhibiting inflammation and antioxidant stress.

关 键 词：Sweet potato leaves Ethanol extract Liver injury Protective effect 

分 类 号：R285.5[医药卫生—中药学]