冠心病患者支架植入术前后血清circCHFR水平的变化及其意义  

Changes and Clinical Significance of Serum circCHFR Level in Patientswith Coronary Heart Disease Before and After Stent Implantation

作　　者：王海涛[1] 马翠[2] 石奇松[1] 陈伟[1] 王彬 WANG Haitao;MA Cui;SHI Qisong;CHEN Wei;WANG Bin(Department of Cardiology,The No.2 Hospital of Baoding,Baoding 071000,China;Department of Stomatology,The No.2 Hospital of Baoding,Baoding 071000,China)

机构地区：[1]保定市第二医院心内二科,河北保定071000 [2]保定市第二医院口腔科,河北保定071000

出　　处：《标记免疫分析与临床》2023年第8期1380-1385,共6页Labeled Immunoassays and Clinical Medicine

摘　　要：目的 探究冠心病(CHD)患者经皮冠状动脉介入治疗(PCI)术前后血清circCHFR水平的变化及其意义。方法随机取样法选取2019年1月至2021年7月在本院经选择性冠状动脉造影(CAG)确诊的CHD患者190例,将患者按照是否接受PCI分为PCI组105例,未接受PCI组85例。应用qRT-PCR法检测血清中circCHFR表达水平;采用酶联免疫吸附法(ELISA)法测定B型脑钠肽(BNP)、C反应蛋白(CRP)、心肌肌钙蛋白Ⅰ(cTnI)的水平;采用Pearson相关性分析血清circCHF表达水平与BNP、CRP、cTnI的相关性。多因素Logistic回归分析PCI术后再狭窄的危险因素,ROC分析血清circCHFR、BNP和cTnI对PCI术后再狭窄的预测价值。结果 PCI组circCHFR、BNP、CRP、cTnI水平显著高于未接受PCI组及对照组,未接受PCI组显著高于对照组(P<0.05);PCI组患者术前1d的circCHFR表达与BNP、CRP、cTnI呈正相关(P<0.05);PCI组术后第30d circCHFR水平显著低于术前1d、术后第1、10d,术后第10d circCHFR水平显著低于术前1d、术后第1d;术后第1d circCHFR水平显著低于术前1d(P<0.05);再狭窄患者术前circCHFR、BNP、CRP、cTnI的水平显著高于未再狭窄患者(P<0.05)。Logistic回归分析果显示,circCHFR、BNP和cTnI表达是PCI术后再狭窄的危险因素(P<0.05)。联合预测的ACU的值显著高于circCHFR、BNP和cTnI单独预测的(Z=4.690,P<0.05;Z=6.840,P<0.05;Z=5.396,P<0.05)。结论 CHD患者血清中circCHFR表达水平显著增高,且在PCI术后随时间的延长逐渐降低。Objective To investigate changes and clinical significance of serum circCHFR level before and after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD).Methods A total of 190 CHD patients diagnosed by selective coronary angiography(CAG)in our hospital from January,2019 to July,2021 were selected by random sampling method,and these patients were divided into a PCI group(105 cases)and a non-PCI group(85 cases)according to whether they received PCI or not.The expression level of circCHFR in serum was detected by qRT-PCR method;The contents of B-type brain natriuretic peptide(BNP),C-reactive protein(CRP)and cardiac troponin I(cTnI)were determined by enzyme-linked immunosorbent assay(ELISA);Pearson correlation method was used to analyze the correlation between serum circCHF expression level and BNP,CRP,cTnI.Multivariate logistic regression was used to analyze the risk factors for restenosis after PCI,and ROC analysis of serum circCHFR,BNP and cTnI in predicting restenosis after PCI.Results Levels of circCHFR,BNP,CRP,and cTnI in the PCI group were significantly higher than those in the non-PCI group and the control group,and the non-PCI group were significantly higher than the control group(P<0.05);circCHFR expression was positively correlated with BNP,CRP and cTnI in PCI group 1 day before surgery(P<0.05);The level of circCHFR in the PCI group on the 30th day after surgery was significantly lower than that on the 1st day before surgery,the 1st and 10th day after surgery,and the level of circCHFR on the 10th day after surgery was significantly lower than that on the 1st day before surgery and the 1st day after surgery;The level of circCHFR on the 1st day after surgery was significantly lower than that on the 1st day before surgery(P<0.05);The preoperative levels of circCHFR,BNP,CRP and cTnI in patients with restenosis were significantly higher than those in patients without restenosis(P<0.05);Logistic regression analysis showed that circCHFR,BNP and cTnI expression were risk factors for

关 键 词：冠心病 支架植入 circCHFR 

分 类 号：R541.4[医药卫生—心血管疾病]