首发抑郁症双侧海马静息态和动态功能连接特征的fMRI研究  

A study of altered resting state and dynamic functional connectivity characteristics of the hippocampus bilaterally in first-episode depression

作　　者：曹久冬 王小玲[1] 张磊[1] 洪洋[1] 张国雷 包岩[1,2] 罗萍 孙黎[1] 韩铭[1] 吕学玉[1] 刘军[1] 姚晓燕[1] 李珊珊[1] 孙继飞[1] 方继良 CAO Jiudong;WANG Xiaoling;ZHANG Lei;HONG Yang;ZHANG Guolei;BAO Yan;LUO Ping;SUN Li;HAN Ming;LÜXueyu;LIU Jun;YAO Xiaoyan;LI Shanshan;SUN Jifei;FANG Jiliang(Department of Radiology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Radiology,Dalian Branch of Shengjing Hospital Affiliated to China Medical University,Dalian 116600,China)

机构地区：[1]中国中医科学院广安门医院放射科,北京100053 [2]中国医科大学附属盛京医院大连医院放射科,大连116600

出　　处：《磁共振成像》2023年第10期7-11,30,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81303056);中国中医科学院科技创新工程项目(编号:CI2021A03304、CI2021A03312、CI2021A03106)。

摘　　要：目的 观察首发抑郁症(first-episode depression, FDE)患者双侧海马静息态和动态功能连接(dynamic functional connectivity, dFC)特征改变及与临床症状的相关性。材料与方法 回顾性分析26例FDE患者(FDE组)和20例健康对照(healthy controls, HCs)组,分别对两组受试者行静息态功能MRI(resting-state functional MRI, rs-fMRI)扫描,以双侧海马为种子点,观察两组双侧海马的静息态功能连接(static functional connectivity, sFC)和dFC差异,并完成FDE患者临床抑郁量表的评定,分析差异脑区与临床症状的相关性。结果 与HCs组相比,FDE组左侧海马与右侧眶部额中回的sFC降低,右侧海马与右侧中央前回的sFC降低。与HCs组相比,FDE组左侧海马与右侧辅助运动区、右侧中央前回的dFC降低,右侧海马与左侧中央前回的dFC降低,与右侧枕下回的dFC增高。相关性分析发现,FDE组右侧海马与右侧枕下回的dFC值和24项汉密尔顿抑郁量表评分呈正相关(r=0.474, P=0.015)。结论 FDE患者双侧海马与奖赏网络、感觉运动网络的sFC存在异常改变,与感觉运动网络和视觉加工皮层的dFC存在异常改变,这为理解FDE患者的神经病理机制及靶向治疗提供了一定借鉴意义。Objective:To observe bilateral hippocampal static state and dynamic functional connectivity(dFC)features and association with clinical symptoms in first episode depression(FDE).Materials and Methods:Twenty-six FDE patients(FDE group)and 20 healthy controls(HCs group)were retrospectively included.rs-fMRI scans were performed on the two groups of subjects,and after using the bilateral hippocampus as the seed point,the resting state functional connectivity(sFC)and dynamic functional connectivity(dFC)differences between the two groups were observed.The differences of sFC and dFC between the two groups were observed,and the clinical depression scale of FDE patients was completed to analyze the correlation between the different brain regions and clinical symptoms.Results:Compared with the HCs group,the sFC of the left hippocampus with the right orbitofrontal middle gyrus was decreased in the FDE group,and the sFC of the right hippocampus with the right precentral gyrus was decreased.Compared with the HCs group,the dFC of the left hippocampus with the right supplementary motor area and the right precentral gyrus was decreased in the FDE group,and the dFC of the right hippocampus with the left precentral gyrus was decreased and increased with the dFC of the right inferior occipital gyrus.Correlation analysis revealed a positive correlation between dFC values in the right hippocampus with the right suboccipital gyrus and 24-item Hamilton Rating Scale for Depression,scores in the FDE group(r=0.474,P=0.015).Conclusions:The presence of abnormal alterations in the sFC of the hippocampus and reward network and sensorimotor network bilaterally with abnormal alterations in the dFC of the sensorimotor network and visual processing cortex in FDE patients provides some implications for understanding the neuropathological mechanisms and targeted therapies in FDE patients.

关 键 词：首发抑郁症 静息态功能磁共振成像 磁共振成像 海马 静息态功能连接 动态功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]